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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
92 Results for "
ATP-binding cassette
" in MedChemExpress (MCE) Product Catalog:
Products (92)
92 Results for "ATP-binding cassette" in MCE Product Catalog:
55
55 Publications Verification
Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters .
3
3 Cited Publications
Cat. No.: HY-W004500
CAS No.: 116-31-4
Category:
Human Gut Microbiota Metabolites Terpenoids Other Diseases Diterpenoids Microorganism Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Target:
Research Areas:
A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter .
2
2 Cited Publications
Cat. No.: HY-N0248
CAS No.: 58316-41-9
Category:
Umbelliferae/Apiaceae Extract Infection Triterpenes Plant Terpenoids Bupleurum chinensis DC. Extract Disease Research Fields
Target:
2
1
Research Areas:
Vorolanib (CM082) is an orally active, potent multikinase VEGFR/PDGFR inhibitor. Vorolanib is a potent ATP-binding cassette (ABC) transporter inhibitor. Vorolanib is an angiogenesis inhibitor and has antitumor activity combined with ZD1839 (HY-50895) .
1
1 Cited Publications
G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket .
1
1 Cited Publications
Synonyms: 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
Target:
Research Areas:
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE -/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .
1
1 Cited Publications
Target:
Research Areas:
MY-5445 is a specific inhibitor of the cyclic GMP phosphodiesterase, phosphodiesterase type 5 (PDE5), with a Ki of 1.3 μM. MY-5445 inhibits human platelet aggregation. MY-5445 is a selective modulator of ATP-binding cassette (ABC) transporter ABCG2, with anti-proliferative effect .
1
1
1 Cited Publications
Cat. No.: HY-P703175
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. MDR1; Phospholipid Transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; Multidrug Resistance Protein 1; ATP-binding cassette Sub-Family B Member 1; ATP-binding cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P81118
Synonyms: CMOAT; CMOAT1; CMRP; MRP2; ABCC2; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2
Target:
Research Areas:
TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1 .
Cat. No.: HY-W014118
CAS No.: 101-86-0
Target:
Synonyms: CID44640177; SID 88095709
ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2, and 36-fold selective for ABCG2 over ABCB1 with EC50s values of 0.13 μM and 4.65 μM, respectively .
Cat. No.: HY-145417
CAS No.: 2909443-24-7
G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter. Transmembrane ATP-binding cassette (ABC) transporters are crucial cellular machines that move molecules small and large across membranes. G092 has the potential for the research of antimicrobial agents .
Cat. No.: HY-N13361
Category:
Other Terpenoids Natural Products Plant Terpenoids Hypericaceae Extract Hypericum elodeoides Choisy Extract
Target:
Cat. No.: HY-136870
CAS No.: 2088021-81-0
Target:
Research Areas:
Kyoto probe 1 is a hiPSCs fluorescent probe. Kyoto probe 1 selectively labels human pluripotent stem cells. Kyoto probe 1 is primarily explained by the distinct expression patterns of ATP-binding cassette (ABC) transporters by hiPS cells and differentiated cells .
Cat. No.: HY-P703084
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCA2; ATP-binding cassette 2; Prev. ABC2; ATP-binding cassette Protein; ATP-binding cassette Sub-Family A Member 2; ABCA2 Protein; ATP-binding cassette Transporter 2; KIAA1062; ATP-binding cassette, Sub-Family A (ABC1), Member 2; IDPOGSA; ATP binding Cas
Species:
Human
Source:
HEK293
Cat. No.: HY-168572
CAS No.: 2944457-11-6
MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
