11

ADH-1

11 Cited Publications

Cat. No.: HY-13541

CAS No.: 229971-81-7

Purity: 99.93%

Target:

Cadherin

Research Areas:

Cancer

ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.

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11

ADH-1 trifluoroacetate

11 Cited Publications

Cat. No.: HY-13541A

CAS No.: 1135237-88-5

Purity: 99.74%

Target:

Cadherin

Research Areas:

Cancer

ADH-1 trifluoroacetate is an N-cadherin antagonist, which inhibits N-cadherin mediated cell adhesion.

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3

ADH-503

3 Cited Publications

Cat. No.: HY-15701B

CAS No.: 2055362-74-6

Purity: 98.04%

Synonyms: (Z)-Leukadherin-1 choline

Target:

Complement System

Research Areas:

Cancer

ADH-503 ((Z)-Leukadherin-1 choline) is an orally active and allosteric CD11b agonist. ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses .

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1

Isovaleramide

1 Cited Publications

Cat. No.: HY-B1229

CAS No.: 541-46-8

Synonyms: 3-Methylbutanamide

Category:

Natural Products Plants Other Families Extract

Target:

GABA Receptor

Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1] .

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Isochenodeoxycholic acid

Cat. No.: HY-N4067

CAS No.: 566-24-5

Synonyms: isoCDCA

Category:

Natural Products

Target:

FXR Endogenous Metabolite

Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .

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Sorbitol dehydrogenase-IN-1

Cat. No.: HY-118980

CAS No.: 300551-49-9

Purity: 98.70%

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Metabolic Disease

Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC₅₀ s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol .

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ADH-6 TFA

Cat. No.: HY-145785A

CAS No.: 2990065-87-5

Purity: 99.67%

Target:

MDM-2/p53 Apoptosis

Research Areas:

Cancer

ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases .

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Nicotinamide-guanine dinucleotide sodium

Cat. No.: HY-164690A

CAS No.: 2600354-60-5

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease

Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro .

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AXT-914

Cat. No.: HY-177303

CAS No.: 717104-43-3

Target:

CaSR SARS-CoV

Research Areas:

Infection Metabolic Disease Endocrinology

AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research .

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