2 Results for "

Alphitolic acid

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Alphitolic acid" in MCE Product Catalog:

Alphitolic acid
Alphitolic acid
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Cat. No.: HY-N2855
CAS No.: 19533-92-7
Synonyms: Aophitolic acid
Category:  

Myrica nagi /Podocarpus nagi Extract Podocarpaceae Extract Triterpenes Plant

Target:  

Apoptosis Autophagy TNF Receptor Akt NF-κB Bacterial Parasite

Alphitolic acid (Aophitolic acid), an anti-inflammatory triterpenoid compound, is a selective HMGCS2 inhibitor (IC50 17.17 μM, Kd 5.6 μM). Alphitolic acid inhibits ORAI1/STIM1-mediated CRAC currents, store-operated calcium entry, the Akt-mTOR-NF-κB signaling pathway, p70S6K/S6/IκBα phosphorylation, NF-κB/Bcl-2 expression, and NO/TNF-α production, while upregulating p53 and downregulating MDM2. Alphitolic acid induces apoptosis (apoptosis) and autophagy (autophagy) through Beclin 1, Atg7, LC3B-II, and autophagosomes, inhibits oral squamous cell carcinoma proliferation/viability, and exhibits antibacterial/antimalarial/antioxidant activities. Alphitolic acid can be used in research on inflammatory diseases, allergic diseases, Tamoxifen (HY-13757A)-resistant breast cancer, oral squamous cell carcinoma, and inflammation .
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2-O-trans-p-Coumaroylalphitolic acid
2-O-trans-p-Coumaroylalphitolic acid
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Cat. No.: HY-N12744
CAS No.: 67911-63-1
Category:  

Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Extract Triterpenes Plant Terpenoids Rhamnaceae Extract

Target:  

Glucocorticoid Receptor

2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity .
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