7987 Results for "

Antagonist

" in MedChemExpress (MCE) Product Catalog:

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246

Enzalutamide

246 Publications Verification

Cat. No.: HY-70002

CAS No.: 915087-33-1

Synonyms: MDV3100

Target:

Androgen Receptor Autophagy

Research Areas:

Cancer

Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .

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232

GW9662

232 Cited Publications

Cat. No.: HY-16578

CAS No.: 22978-25-2

Target:

PPAR

Research Areas:

Cancer

GW9662 is a potent and selective PPARγ antagonist with an IC₅₀ of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.

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183

H-151

183 Cited Publications

Cat. No.: HY-112693

CAS No.: 941987-60-6

Purity: 99.78%

Target:

STING

Research Areas:

Inflammation/Immunology

H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease .

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179

Clozapine N-oxide

179 Cited Publications

Cat. No.: HY-17366

CAS No.: 34233-69-7

Target:

Drug Metabolite mAChR Dopamine Receptor

Research Areas:

Neurological Disease

Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

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179

Clozapine N-oxide dihydrochloride

179 Cited Publications

Cat. No.: HY-17366A

CAS No.: 2250025-93-3

Target:

mAChR Dopamine Receptor Drug Metabolite

Research Areas:

Neurological Disease

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

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149

Fulvestrant

149 Cited Publications

Cat. No.: HY-13636

CAS No.: 129453-61-8

Purity: 99.92%

Synonyms: ICI 182780; ZD 9238; ZM 182780

Target:

Estrogen Receptor/ERR Autophagy Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .

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126

CH-223191

126 Cited Publications

Cat. No.: HY-12684

CAS No.: 301326-22-7

Purity: 99.96%

Target:

Aryl Hydrocarbon Receptor

Research Areas:

Cancer

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

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116

Plerixafor octahydrochloride

116 Cited Publications

Cat. No.: HY-50912

CAS No.: 155148-31-5

Synonyms: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride

Target:

CXCR HIV Virus Protease

Research Areas:

Inflammation/Immunology Endocrinology Cancer

Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM.

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116

Plerixafor

116 Cited Publications

Cat. No.: HY-10046

CAS No.: 110078-46-1

Purity: 99.90%

Synonyms: AMD 3100; JM3100; SID791

Target:

CXCR HIV

Research Areas:

Infection Inflammation/Immunology Endocrinology Cancer

Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

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GW6471

88 Cited Publications

Cat. No.: HY-15372

CAS No.: 880635-03-0

Purity: 99.64%

Target:

PPAR Apoptosis

Research Areas:

Cancer

GW6471 is a selective peroxisome proliferator-activated receptor α (PPARα) antagonist. GW6471 reduces cancer stem cell viability, proliferation, and spheroid formation. GW6471 induces apoptosis and causes metabolic impairment including energy imbalance. GW6471 can be used for the research of paragangliomas and triple-negative breast cancer .

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Fingolimod hydrochloride

82 Cited Publications

Cat. No.: HY-12005

CAS No.: 162359-56-0

Purity: 99.95%

Synonyms: FTY720

Target:

LPL Receptor PAK

Research Areas:

Inflammation/Immunology Cancer

Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant .

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Fingolimod

82 Cited Publications

Cat. No.: HY-11063

CAS No.: 162359-55-9

Purity: 99.97%

Synonyms: FTY720 free base

Target:

LPL Receptor PAK

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

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Mifepristone

81 Cited Publications

Cat. No.: HY-13683

CAS No.: 84371-65-3

Purity: 99.83%

Synonyms: RU486; RU 38486

Target:

Endogenous Metabolite Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy

Research Areas:

Endocrinology Cancer

Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

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Colchicine

80 Cited Publications

Cat. No.: HY-16569

CAS No.: 64-86-8

Category:

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:

Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)

Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

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Minocycline hydrochloride

76 Cited Publications

Cat. No.: HY-17412

CAS No.: 13614-98-7

Target:

Bacterial Antibiotic HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

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Minocycline

76 Cited Publications

Cat. No.: HY-17412A

CAS No.: 10118-90-8

Target:

Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel

Research Areas:

Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

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Glycyrrhizic acid

68 Cited Publications

Cat. No.: HY-N0184

CAS No.: 1405-86-3

Synonyms: Glycyrrhizin

Category:

Triterpenes Terpenoids Metabolic Disease 500 - Internal Server Error | MedChemExpress

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