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33 Results for "

Anti-Parasite

" in MedChemExpress (MCE) Product Catalog:

Products (33)

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Ivermectin

51 Publications Verification

Cat. No.: HY-15310

CAS No.: 70288-86-7

Purity: 98.28%

Synonyms: MK-933; CD-5024; K-237

Category:

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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Furamidine dihydrochloride

4 Cited Publications

Cat. No.: HY-110137

CAS No.: 55368-40-6

Purity: ≥99.0%

Synonyms: DB75 dihydrochloride; NSC 305831 dihydrochloride

Target:

Histone Methyltransferase Phosphodiesterase (PDE) Parasite

Research Areas:

Infection Inflammation/Immunology Cancer

Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

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Albendazole sulfoxide

3 Cited Publications

Cat. No.: HY-12785

CAS No.: 54029-12-8

Purity: 99.20%

Synonyms: Ricobendazole; Albendazole oxide

Target:

Parasite

Research Areas:

Infection

Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .

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Columbamine

3 Cited Publications

Cat. No.: HY-N0926

CAS No.: 3621-36-1

Synonyms: Columbamin; Dehydroisocorypalmine

Category:

Other Diseases Plants Other Families Extract Disease Research Fields

Target:

Cytochrome P450 Apoptosis Parasite

Columbamine (Columbamin; Dehydroisocorypalmine) is an organic heterotetracyclic alkaloid extracted from plants. Columbamine is a metabolite of Berberine (HY-N0716). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). Columbamine induces apoptosis in cancer cells. Columbamine can be used for antioxidant, anti-inflammatory, antitumor, antifungal, antiparasite, hepatoprotective, neuroprotective, hypolipidemic and hypoglycemic study .

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