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11 Results for "

AuroraB

" in MedChemExpress (MCE) Product Catalog:

Products (11)

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JNJ-7706621

4 Cited Publications

Cat. No.: HY-10329

CAS No.: 443797-96-4

Purity: 99.91%

Target:

Aurora Kinase CDK Apoptosis

Research Areas:

Cancer

JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively .

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JB170

3 Cited Publications

Cat. No.: HY-141512

CAS No.: 2705844-82-0

Purity: 98.97%

Target:

PROTACs Aurora Kinase

Research Areas:

Cancer

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC₅₀=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC₅₀=193 nM) over AURORA-B (EC₅₀=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase .

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CCT241736

Cat. No.: HY-18161

CAS No.: 1402709-93-6

Target:

FLT3 Aurora Kinase

Research Areas:

Cancer

CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A K_d, 7.5 nM, IC₅₀, 38 nM; Aurora-B K_d, 48 nM), FLT3 kinase (K_d, 6.2 nM), and FLT3 mutants including FLT3-ITD (K_d, 38 nM) and FLT3(D835Y) (K_d, 14 nM).

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dAurAB5

Cat. No.: HY-171770

CAS No.: 3115765-45-9

Target:

PROTACs Aurora Kinase AAK1

Research Areas:

Neurological Disease Cancer

dAurAB5 is a potent Aurora-A/Aurora-B PROTAC degrader with DC₅₀ values of 8.8 nM and 6.1 nM, respectively. dAurAB5 promotes proteasomal degradation of target proteins, induces ubiquitination of Aurora-A and Aurora-B kinases, and downregulates the protein levels of TTK and MYCN. dAurAB5 can be used in studies related to neuroblastoma [1].

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dAurAB2

Cat. No.: HY-171769

CAS No.: 3115765-38-0

Research Areas:

Neurological Disease Cancer

dAurAB2 is a potent Aurora-A/Aurora-B PROTAC degrader with DC₅₀ values of 59 nM and 39 nM, respectively. dAurAB2 induces ubiquitination and proteasomal degradation of Aurora-A kinase and Aurora-B kinase, and indirectly reduces N-Myc protein levels. dAurAB2 can be used in studies related to neuroblastoma .

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