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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Autotoxin
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Autotoxin" in MCE Product Catalog:
Target:
Research Areas:
Autotaxin-IN-3 is a Autotaxin(ATX) inhibitor with an IC50 of 2.4 nM, compound 33, sourced from patent WO2018212534A1 .
Target:
Research Areas:
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer .
Cat. No.: HY-150614
CAS No.: 2800898-98-8
Target:
Research Areas:
Autotaxin-IN-6 (compound 23) is a potent autotaxin (ATX) inhibitor with an IC50 value of 30 nM. Autotaxin-IN-6 can reduce cell migration. Autotaxin-IN-6 can be used for researching anticancer .
Cat. No.: HY-135088
CAS No.: 2156655-86-4
Target:
Research Areas:
Autotaxin-IN-4 (compound 51), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-4 has the potential to treat idiopathic pulmonary fibrosis .
Cat. No.: HY-123637
CAS No.: 1619971-30-0
Target:
Research Areas:
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain .
Cat. No.: HY-135089
CAS No.: 2156655-99-9
Target:
Research Areas:
Autotaxin-IN-5 (compound 63), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-5 has the potential to treat idiopathic pulmonary fibrosis .
Cat. No.: HY-170227
Research Areas:
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .
Cat. No.: HY-181931
CAS No.: 3058084-21-9
Research Areas:
Autotaxin-IN-8 (Compound 14E) is an orally active Autotaxin inhibitor with an IC50 of 14.2 nM against hAutotaxin. Autotaxin-IN-8 inhibits Autotaxin activity, MAPK activation, LPAR1 and p-ERK1/2. Autotaxin-IN-8 reduces the phosphorylation levels of JNK and p38. Autotaxin-IN-8 decreases collagen deposition in a mouse model of pulmonary fibrosis. Autotaxin-IN-8 can be used in research related to pulmonary fibrosis .
Cat. No.: HY-P70167
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ENPP2; LysoPLD; Prev. PDNP2; Phosphodiesterase I/Nucleotide Pyrophosphatase 2; Autotaxin; Plasma Lysophospholipase D; ATX; Alternative Protein ENPP2; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2; Autotaxin-T; Extracellular Lysophosphol
Species:
Human
Source:
HEK293
Cat. No.: HY-P75733
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ENPP2; LysoPLD; Prev. PDNP2; Phosphodiesterase I/Nucleotide Pyrophosphatase 2; Autotaxin; Plasma Lysophospholipase D; ATX; Alternative Protein ENPP2; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2; Autotaxin-T; Extracellular Lysophosphol
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P703781
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ENPP2; LysoPLD; Prev. PDNP2; Phosphodiesterase I/Nucleotide Pyrophosphatase 2; Autotaxin; Plasma Lysophospholipase D; ATX; Alternative Protein ENPP2; Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2; Autotaxin-T; Extracellular Lysophosphol
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
