country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

54 Results for "

BAD

" in MedChemExpress (MCE) Product Catalog:

Products (54)

Sort by :

Categories

By Targets

Species:

Tags:

Sources:

Hosts:

Reactivities:

Applications:

Isotypes:

Conjugations:

Clonalities:

Modifications:

Products

Bafetinib

14 Publications Verification

Cat. No.: HY-50868

CAS No.: 859212-16-1

Synonyms: INNO-406; NS-187

Target:

Bcr-Abl Src Apoptosis

Research Areas:

Cancer

Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

Dapivirine

2 Cited Publications

Cat. No.: HY-14266

CAS No.: 244767-67-7

Purity: 99.80%

Synonyms: TMC120; R147681

Target:

HIV Reverse Transcriptase Apoptosis Autophagy

Research Areas:

Infection

Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

ML281

2 Cited Publications

Cat. No.: HY-13495

CAS No.: 1404437-62-2

Purity: 99.91%

Target:

STK33 PKA Aurora Kinase Bcl-2 Family Apoptosis

Research Areas:

Metabolic Disease Cancer

ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC₅₀ value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion . ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia . ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage

Compare

Please select quantity

August 31

Get Quote

View All Sizes

trans-Vaccenic acid

1 Cited Publications

Cat. No.: HY-113427

CAS No.: 693-72-1

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Bcl-2 Family Apoptosis

trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity .

Compare