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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
BE
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "BE" in MCE Product Catalog:
4
Research Areas:
MS-444 (BE-34776) is a HuR (ELAVL1) inhibitor that blocks the cytoplasmic translocation of HuR and inhibits its dimerization. MS-444 reduces cytoplasmic HuR levels by preventing the binding of HuR to ARE-mRNA, without altering the total expression of HuR. MS-444 induces apoptosis, inhibits cell growth, angiogenesis and invasion, and also regulates immune function and microbiota. MS-444 effectively alters the number, size and invasiveness of tumors in various cancer models. MS-444 is tolerable to intraperitoneal injection in vivo and can be applied to research related to colorectal cancer, familial adenomatous polyposis, colitis-associated cancer and glioblastoma .
Cat. No.: HY-114203
CAS No.: 88798-74-7
Synonyms: BE003
Target:
Cat. No.: HY-13610
CAS No.: 121749-39-1
Synonyms: Diethylnorspermine; BENSPM; DENSPM; BE-333
N1,N11-Diethylnorspermine is a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
Cat. No.: HY-117092
CAS No.: 158054-02-5
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BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells .
Cat. No.: HY-121783
CAS No.: 40077-13-2
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BE2254 is a compound with antipyretic and metabolic activity, which has the activity of regulating the febrile response and metabolism. BE2254 can reduce the metabolic and febrile activity induced by lipopolysaccharide in febrile rabbits, suggesting that it may regulate body temperature by acting on the α1-adrenergic receptor mechanism.
Cat. No.: HY-138211
CAS No.: 147716-81-2
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BE-26263, an antiosteoporotic agent that can be isolated from Scedosporium apiospermum, possesses estrogenic effect .
Cat. No.: HY-167671
CAS No.: 135261-89-1
Category:
Target:
Cat. No.: HY-170571
Target:
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BE2647 is a selective inhibitor for mitochondrial pyruvate carrier (MPC) with an EC50 of 70 nM. BE2647 exhibits good metabolic stability in mouse liver microsomes. BE2647 can be used in research of metabolic diseases, non-alcoholic fatty liver disease (MASLD), or non-alcoholic steatohepatitis (MASH) .
Cat. No.: HY-N10155A
CAS No.: 147138-01-0
Target:
Cat. No.: HY-100980
CAS No.: 30007-39-7
Synonyms: BE2254 hydrochloride
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HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively .
Cat. No.: HY-W781265
CAS No.: 149466-04-6
Synonyms: L-755,805
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BE 24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger. It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs=1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/mL, respectively). BE 24566B is an endothelin (ET) receptor antagonist (IC50s=11 and 3.9 μM for ETA and ETB receptors, respectively).
Cat. No.: HY-RS17248
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Pomc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pomc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-180944
CAS No.: 667889-47-6
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BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels .
Cat. No.: HY-184660
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Research Areas:
BE21349 is a carbonic anhydrase (CA) inhibitor with Ki values of 2090, 17.1, 61.8, and 40.5 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. BE21349 exhibits submicromolar inhibitory activity against leukemia, non-small cell lung cancer, and melanoma cell lines. BE21349 can be used in cancer-related research such as leukemia, non-small cell lung cancer, and melanoma .
Cat. No.: HY-120015
CAS No.: 137530-61-1
BE-16627B is a metalloproteinase inhibitor. BE-16627B can be isolated from microbial cultures. BE-16627B can inhibit metalloproteinases in enzyme assays. BE-16627B reduces the number and size of HT1080 cell nodules on lung surface in mouse models. BE-16627B inhibits growth of HT1080 cells in mice. BE-16627B can be studied in anti-cancer research .
Cat. No.: HY-P991819
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Cat. No.: HY-P76381
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: H2BC21; H2B Histone Family, MemBEr Q; Prev. HIST2H2BE; Histone H2B Type 2-E; Prev. H2BFQ; Histone H2B-GL105; Prev. H2B; Histone 2, H2BE; H2B-GL105; Histone H2B.Q; H2B/Q; H2B-Clustered Histone 21; H2B.1; H2BGL105; H2BE; GL105; Histone Cluster 2 H2B Family
Species:
Human
Source:
E. coli
Cat. No.: HY-P70363
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTBR; Tumor Necrosis Factor Receptor Type III; Prev. D12S370; TNFR3; TNFRSF3; Lymphotoxin BEta Receptor (TNFR Superfamily, MemBEr 3); TNFCR; TNFR Superfamily, MemBEr 3; TNF-R-III; Lymphotoxin-BEta Receptor; TNFR2-RP; Lymphotoxin B Receptor; TNFR-RP; LT-BE
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
