4

4-DAMP

4 Cited Publications

Cat. No.: HY-100958

CAS No.: 1952-15-4

Purity: 99.96%

Synonyms: 4-DAMP methiodide

Target:

mAChR Apoptosis MMP EGFR Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .

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1

LSD1-IN-27

1 Cited Publications

Cat. No.: HY-155115

CAS No.: 2904571-94-2

Purity: 98.88%

Target:

Histone Demethylase PD-1/PD-L1

Research Areas:

Cancer

LSD1-IN-27 is an orally active LSD1 inhibitor (IC₅₀: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .

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TRPM7-IN-1

Cat. No.: HY-168608

CAS No.: 1909225-07-5

Target:

TRP Channel Apoptosis PI3K Akt

Research Areas:

Cancer

TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function .

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TrxR1-IN-1

Cat. No.: HY-149390

CAS No.: 3052303-04-2

Target:

TrxR Free Radical Scavengers

Research Areas:

Cancer

TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC₅₀: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC₅₀s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical .

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1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione

Cat. No.: HY-N16377

CAS No.: 1644075-01-3

Category:

Quinones Microorganisms Anthraquinones

Target:

Others

1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione (Compound 2) is an anthraquinone analog. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione can be isolated from soil Actinomycete Streptomyces. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione has potent cytotoxicity against HepG2, A875, BGC-823 and MCF-7 cells with IC₅₀s of 2.29, 4.90, 0.99 and 1.66 μg/mL, respectively. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione has an antitumor activity .

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GL-1196

Cat. No.: HY-124398

CAS No.: 591242-70-5

Target:

PAK

Research Areas:

Cancer

GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research .

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Apoptosis inducer 25

Cat. No.: HY-163924

CAS No.: 2763063-15-4

Target:

Apoptosis

Research Areas:

Cancer

Apoptosis inducer 25 (Compound 4H) inhibits the proliferation of cell BGC-823 with IC₅₀ of 0.37 μM. Apoptosis inducer 25 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 25 exhibits good pharmacokinetic properties in rats .

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