10599 Results for "

BMPR2 activation

" in MedChemExpress (MCE) Product Catalog:

Products (10599)

Sort by :

Categories

By Targets

Species:

Tags:

Sources:

Hosts:

Reactivities:

Applications:

Isotypes:

Conjugations:

Clonalities:

Modifications:

Products

2335

MG-132

2335 Publications Verification

Cat. No.: HY-13259

CAS No.: 133407-82-6

Purity: 99.90%

Synonyms: Z-Leu-Leu-Leu-al; MG132

Target:

Proteasome Autophagy Apoptosis

Research Areas:

Cancer

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis ^[2] .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

1510

Rapamycin

1510 Cited Publications

Cat. No.: HY-10219

CAS No.: 53123-88-9

Purity: 99.94%

Synonyms: Sirolimus; AY-22989; NSC 226080

Category:

Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Anti-aging Antibiotics Disease Research Disease Research Fields Cancer

Target:

mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial

Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant ^[2] .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

1253

LY294002

1253 Cited Publications

Cat. No.: HY-10108

CAS No.: 154447-36-6

Purity: 99.86%

Target:

PI3K Casein Kinase DNA-PK Apoptosis Autophagy

Research Areas:

Infection Cancer

LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC₅₀ of 98 nM ^[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

899

Cisplatin

899 Cited Publications

Cat. No.: HY-17394

CAS No.: 15663-27-1

Synonyms: cis-Platinum; CDDP; cis-Diaminodichloroplatinum

Target:

DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase

Research Areas:

Cancer

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy ^[2] .

Compare