3

FT113

3 Cited Publications

Cat. No.: HY-111551

CAS No.: 1630808-89-7

Purity: 99.39%

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC₅₀ of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC₅₀, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

ORM-5029

Cat. No.: HY-164202

Target:

Antibody-Drug Conjugates (ADCs) EGFR Eukaryotic Release Factor (eRF)

Research Areas:

Cancer

ORM-5029 is a first-in-class human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate (ADC) comprised of SMol006, a highly potent GSPT1 degrader, conjugated to Pertuzumab (HY-P9912). ORM-5029 exhibits robust efficacy across 14 HER2-positive breast cancer cell lines, with IC₅₀ values ranging from 0.3 to 14.4 nM.ORM-5029 demonstrates anti-tumor activity in the BT474 xenograft model. ORM-5029 can be used for study of breast cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Perzebertinib

Cat. No.: HY-163428

CAS No.: 2414056-31-6

Synonyms: ZN-A-1041

Target:

EGFR

Research Areas:

Inflammation/Immunology Cancer

ZN-A-1041 inhibits HER2 in BT474 cell and wt-EGFR in H838 cells, with IC₅₀s of 9.5 nM and 12 μM respectively. ZN-A-1041 can be used for research of cancer and inflammation .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

AG 1406

Cat. No.: HY-108931

CAS No.: 71308-34-4

Purity: 99.03%

Target:

EGFR

Research Areas:

Cancer

AG 1406 (compound M19) is a HER2 inhibitor, with an IC₅₀ of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

SST0116CL1

Cat. No.: HY-164399

CAS No.: 1799802-29-1

Target:

HSP EGFR CDK Akt

Research Areas:

Cancer

SST0116CL1 is a HSP90 inhibitor (IC₅₀: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC₅₀: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth. SST0116CL1 can be used for the study of leukemia, gastric and ovarian carcinoma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

MS98

Cat. No.: HY-145281

CAS No.: 2376137-31-2

Target:

PROTACs Akt PI3K mTOR

Research Areas:

Cancer

MS98 is a AKT PROTAC degrader with a DC₅₀ of 78 nM in BT474 cells. MS98 binds to purified AKT1, AKT2 and AKT3 isoforms with K_d values of 4 nM, 140 nM and 8 nM, respectively. MS98 recruits the VHL E3 ligase to induce polyubiquitination and proteasomal degradation of AKT. MS98 inhibits downstream signal transduction of the PI3K/AKT/m-TOR pathway. MS98 suppresses cancer cell proliferation. MS98 can be used for the research of prostate cancer and breast cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Thailanstatin A cyclohexane diamine formic

Cat. No.: HY-160899A

Target:

Drug-Linker Conjugates for ADC

Research Areas:

Cancer

Thailanstatin A cyclohexane diamine formic is an analog of Spliceostatin (HY-16466). Thailanstatin A cyclohexane diamine formic inhibits proliferations of cells N87 (IC₅₀ is 0.33 μM), BT474 (IC₅₀ is 0.34 μM), MDA-MB-361-DYT2 (IC₅₀ is 0.88 μM) and MDA-MB-468 (IC₅₀ is 0.27 μM). Thailanstatin A cyclohexane diamine formic is used as a drug-linker conjugate for ADC molecule .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Iturin A-2

Cat. No.: HY-P10785

CAS No.: 83785-07-3

Target:

Bacterial Antibiotic

Research Areas:

Infection

Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC₅₀ values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

BTK-IN-38

Cat. No.: HY-169307

CAS No.: 2758410-51-2

Target:

Btk

Research Areas:

Cancer

BTK-IN-38 (Example 125) is a potent BTK inhibitor. BTK-IN-38 inhibits DOHH2 and BT474 cells proliferation with IC₅₀s of 114 and 340 nM, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

EGFR/HER2-IN-11

Cat. No.: HY-160613

CAS No.: 1346176-20-2

Target:

EGFR

Research Areas:

Cancer

EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC₅₀s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI₅₀ of 601 nM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

CNBCA

Cat. No.: HY-155098

CAS No.: 3044817-00-4

Target:

SHP2

Research Areas:

Cancer

CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC₅₀ of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study .

Compare

loading...