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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
BTX
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "BTX" in MCE Product Catalog:
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3 Cited Publications
Synonyms: Casein Kinase inhibitor A51
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BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .
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1 Cited Publications
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BTX161, a Thalidomide (HY-14658) analog, is a molecular glue degrader targeting CK1α. BTX161 recruits CK1α and the CK1α-FAM83 complex to the Cul4ACRBN E3 ligase complex, thereby driving ubiquitination and proteasomal degradation. BTX161 reduces FAM83G abundance through CK1α-FAM83G co-stability, slightly decreases FAM83H levels, but has no effect on the expression of FAM83B. BTX161 activates DNA damage response (DDR) and upregulates Wnt target genes including MYC. BTX161 can be used in research related to colorectal cancer, type b myelomonocytic leukemia and acute myeloid leukemia .
Cat. No.: HY-161235
BTX-7312 is a potent SOS1 molecular glue degrader. BTX-7312 forms a ternary complex by linking the target protein SOS1 with the E3 ubiquitin ligase cereblon, inducing ubiquitination and degradation of SOS1, thereby blocking the RAS/MAPK and PI3K/AKT signaling pathways and consequently inhibiting cell proliferation. BTX-7312 can be used for research on KRAS-driven cancers .
Cat. No.: HY-161233A
BTX-6654 formate is a SOS1 PROTAC degrader. BTX-6654 formate induces ubiquitination and degradation of SOS1 via the proteasomal pathway by bridging SOS1 with the E3 ligase CRBN to form a ternary complex, thereby blocking KRAS activation and downregulating the MAPK signaling pathway (pERK/pS6), and ultimately inhibiting tumor growth. BTX-6654 formate can be used in research on various cancers driven by KRAS mutations .
Cat. No.: HY-161233
BTX-6654 is a SOS1 PROTAC degrader. BTX-6654 induces ubiquitination and degradation of SOS1 via the proteasomal pathway by bridging SOS1 with the E3 ligase CRBN to form a ternary complex, thereby blocking KRAS activation and downregulating the MAPK signaling pathway (pERK/pS6), and ultimately inhibiting tumor growth. BTX-6654 can be used in research on various cancers driven by KRAS mutations .
Cat. No.: HY-177740
CAS No.: 2230747-62-1
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BTX306 is a cereblon-targeting molecular glue degrader. BTX306 reduces myeloma cell viability and induces apoptosis. BTX306 overcomes myeloma cell resistance to Lenalidomide (HY-A0003) or Bortezomib (HY-10227). BTX306 is active against primary myeloma cells, and shows efficacy in vivo. BTX306 can be used for myeloma research .
Cat. No.: HY-124232
CAS No.: 99083-11-1
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BTG 502 is an alkylamide insecticide. BTG 502 can reduce sodium current and antagonize the effect of bat toxin (BTX) on cockroach sodium channels .
Cat. No.: HY-16923
CAS No.: 221019-25-6
Synonyms: BIII-890; BIII-890 CL free acid
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Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na + channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na + channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents .
Cat. No.: HY-161234
CAS No.: 2654741-53-2
KRAS ligand 3 (compound 1) is BTX-6654 target-binding ligand that can bind KRAS inhibitor and diaplay synergistic tumor growth inhibiton .
Cat. No.: HY-RS26265
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Chrna7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chrna7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175896
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SOS1 ligand-3 is a target protein ligand that can be used for the synthesis of PROTACs, such as BTX-6654 (HY-161233).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
