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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
CAR3
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "CAR3" in MCE Product Catalog:
Cat. No.: HY-W011788
CAS No.: 76-84-6
Synonyms: Trt-OH
Research Areas:
Triphenylmethanol (Trt-OH) is an agonist of PXR and CAR1. Triphenylmethanol shows no significant ligand effect on CAR3-dependent transactivation. Triphenylmethanol also serves as an intermediate for the synthesis of AMPKα1 activators. The Triphenylmethanol-Doxorubicin (HY-15142A) conjugate exerts anticancer effects against leukemia, ovarian adenocarcinoma, colorectal cancer, and breast cancer [3] .
Cat. No.: HY-173033
CAS No.: 2530027-71-3
Research Areas:
MI-883 is orally active constitutive androstane receptor (CAR) (EC50 of 73 nM) agonist and pregnane X Receptor (PXR) (IC50 of 100 nM) antagonist. MI-883 binds to CAR and PXR ligand-binding domains, promotes CAR LBD assembly, activates CAR3 variant, stimulates CAR cytoplasmic-nuclear translocation, upregulates CAR target genes, recruits coactivators NCOA1, NCOA2, NCOA3, inhibits basal and agonist-induced PXR activation, downregulates PXR target genes, disrupts PXR-NCOR2 interaction, blocks agonist-mediated PXR-NCOA1 recruitment. MI-883 reduces plasma total cholesterol, LDL cholesterol, and hepatic free cholesterol levels, increases fecal bile acid excretion, regulates genes involved in xenobiotic metabolism, cholesterol homeostasis, and bile acid homeostasis. MI-883 exhibits metabolic stability, liver-predominant distribution, a safety profile with no observed toxicity, and does not stimulate human hepatocyte hypertrophy or hyperplasia. MI-883 can be used for the research of diet-induced hypercholesterolemia .
Cat. No.: HY-W011788R
CAS No.: 76-84-6
Synonyms: Trt-OH (Standard)
Target:
Reference Standards Pregnane X Receptor (PXR) Constitutive Androstane Receptor Drug Intermediate
Research Areas:
Triphenylmethanol (Standard) (Trt-OH (Standard)) is the analytical standard of Triphenylmethanol (HY-W011788). This product is intended for research and analytical applications. Triphenylmethanol (Trt-OH) is an agonist of PXR and CAR1. Triphenylmethanol shows no significant ligand effect on CAR3-dependent transactivation. Triphenylmethanol also serves as an intermediate for the synthesis of AMPKα1 activators. The Triphenylmethanol-Doxorubicin (HY-15142A) conjugate exerts anticancer effects against leukemia, ovarian adenocarcinoma, colorectal cancer, and breast cancer [3] .
Cat. No.: HY-RS01769
Target:
Research Areas:
CA3 Human Pre-designed siRNA Set A contains three designed siRNAs for CA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P7719
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA3; CARbonic Anhydrase III; CARbonic Anhydrase 3; CA-III; CAIII; Epididymis Secretory Sperm Binding Protein Li 167mP; CAR3; CARbonic Anhydrase IIII; CARbonic Anhydrase III, Muscle Specific; CARbonic Anhydrase; CARbonate Dehydratase III; HEL-S-167mP
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
