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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
CRAC Channel
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "CRAC Channel" in MCE Product Catalog:
25
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YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca 2+ signals. YM-584832 is a blocker of store-operated Ca 2+ entry (SOCE) .
18
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Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively .
13
13 Cited Publications
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GSK-7975A is a potent and orally available CRAC channel inhibitor.
6
6 Cited Publications
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Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.
5
5 Cited Publications
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RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways .
5
5 Cited Publications
Cat. No.: HY-113618A
CAS No.: 1219927-22-6
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RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways .
Cat. No.: HY-103071
CAS No.: 1253186-46-7
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GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders .
Cat. No.: HY-122158
CAS No.: 903591-53-7
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CRAC channel inhibitor-1 (compound 55) is a CRAC channel inhibitor. CRAC channel inhibitor-1 can be used in immunology-related research .
Cat. No.: HY-20587
CAS No.: 1249343-86-9
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CRAC intermediate 1 is a key intermediate that can be used in synthesis of a series of CRAC channel inhibitors .
Cat. No.: HY-100831R
CAS No.: 223499-30-7
Synonyms: BTP2 (Standard)
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YM-58483 (Standard) is the analytical standard of YM-58483. This product is intended for research and analytical applications. YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE) .
Cat. No.: HY-124372
CAS No.: 1254979-66-2
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JNJ-46356479 is a blood-brain barrier-penetrant mGluR2/3 allosteric activator. JNJ-46356479 binds to the mGluR2 PAM site to enhance mGluR2 activity, thereby inhibiting presynaptic glutamate release and modulating adenylate cyclase (Adenylate Cyclase), calcium channel (CRAC Channel) activity, and neuronal excitability. JNJ-46356479 exhibits anticonvulsant activity in psychomotor seizures and corneal kindling, and can be used in the study of schizophrenia and epilepsy .
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piCRAC-1 is a potent, photoinducible Ca 2+ release-activated Ca 2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage .
Cat. No.: HY-111325R
CAS No.: 835904-51-3
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Synta66 (Standard) is the analytical standard of Synta66 (HY-111325). This product is intended for research and analytical applications. Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.
Cat. No.: HY-101942R
CAS No.: 1713240-67-5
Synonyms: CM-4620 (Standard)
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Zegocractin (Standard) is the analytical standard of Zegocractin (HY-101942). This product is intended for research and analytical applications. Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
