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1 Cited Publications

Synonyms: CYP19A1; ARO1; CYAR; CYP19; Cytochrome P450 19A1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase

Host:

Rabbit

Application:

WB, IP

Reactivity:

Human, Mouse, Rat

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Monoethyl phthalate

Cat. No.: HY-133668

CAS No.: 2306-33-4

Purity: 96.78%

Category:

Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite

Target:

Drug Metabolite Cytochrome P450 PPAR

Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .

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CYP19A1-IN-2

Cat. No.: HY-150775

CAS No.: 3033282-93-5

Purity: 98.88%

Target:

Cytochrome P450

Research Areas:

Cancer

CYP19A1-IN-2 (Compound 13h) is a nonsteroidal aromatase (CYP19A1) inhibitor (IC₅₀=0.09 nM). CYP19A1-IN-2 has potential for breast cancer research . CYP19A1-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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β-Zearalanol-d4

Cat. No.: HY-N6740S

CAS No.: 1778735-09-3

Target:

Isotope-Labeled Compounds Drug Metabolite Estrogen Receptor/ERR MDM-2/p53 JNK p38 MAPK Apoptosis Cytochrome P450 Sirtuin Autophagy

β-Zearalanol-d₄ is the deuterated-labeled β-Zearalenol (HY-N6741). β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (K_d = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer .

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CYP19A1 Human Pre-designed siRNA Set A

Cat. No.: HY-RS03438

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

CYP19A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP19A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cyp19a1 Mouse Pre-designed siRNA Set A

Cat. No.: HY-RS03439

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Cyp19a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp19a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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CYP19A1 Rat Pre-designed siRNA Set A

Cat. No.: HY-RS03440

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

CYP19A1 Rat Pre-designed siRNA Set A contains three designed siRNAs for CYP19A1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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β-Zearalenol

Cat. No.: HY-N6741

CAS No.: 71030-11-0

Category:

Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Disease Research Antibacterial Disease Research Fields Endocrinology

Target:

Drug Metabolite Estrogen Receptor/ERR MDM-2/p53 JNK p38 MAPK Apoptosis Cytochrome P450 Sirtuin Autophagy

β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (K_d = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer .

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