6

6 Publications Verification

Target:

Research Areas:

SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC₅₀s of 3.7 nM and 70 nM, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Vabicaserin hydrochloride

5 Cited Publications

Cat. No.: HY-111200

CAS No.: 887258-94-8

Purity: 99.47%

Synonyms: SCA-136

Target:

5-HT Receptor

Research Areas:

Neurological Disease Metabolic Disease

Vabicaserin hydrochloride (SCA-136) is a brain-penetrant, orally active, and selective 5-HT_2C receptor agonist (K_i = 3 nM; EC₅₀ = 8 nM). Vabicaserin hydrochloride specifically activates Gq-coupled 5-HT_2C receptors to promote calcium mobilization, thereby selectively reducing dopamine release in the mesolimbic system without affecting the nigrostriatal pathway . Vabicaserin hydrochloride is an antagonist of 5-HT_2A/5-HT_2B receptors. Vabicaserin hydrochloride can be used for research on schizophrenia, obesity, chronic pain, and neurodegenerative diseases (such as Machado-Joseph disease) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

ATI-2341

4 Cited Publications

Cat. No.: HY-P0172

CAS No.: 1337878-62-2

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology Cancer

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

ATI-2341 TFA

4 Cited Publications

Cat. No.: HY-P0172A

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology Cancer

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

Otilonium bromide

3 Cited Publications

Cat. No.: HY-B0499A

CAS No.: 26095-59-0

Synonyms: Octylonium bromide; SP63

Target:

mAChR

Research Areas:

Neurological Disease

Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Cyclic ADP-ribose

2 Cited Publications

Cat. No.: HY-N7395

CAS No.: 119340-53-3

Synonyms: cADPR

Category:

Cardiovascular Disease Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Calcium Channel TRP Channel Endogenous Metabolite

Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Etalocib

2 Cited Publications

Cat. No.: HY-13628

CAS No.: 161172-51-6

Purity: 98.74%

Synonyms: LY293111; VML 295

Target:

Leukotriene Receptor Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Etalocib (LY293111), an orally active leukotriene B₄ receptor antagonist, inhibits the binding of [ ³H]LTB₄, with a K_i of 25 nM. Etalocib (LY293111) prevents LTB₄-induced calcium mobilization with an lC₅₀ of 20 nM. Etalocib (LY293111) induces apoptosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Cyclic ADP-ribose ammonium

2 Cited Publications

Cat. No.: HY-N7395A

Synonyms: cADPR ammonium

Category:

Cardiovascular Disease Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Calcium Channel TRP Channel Endogenous Metabolite

Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Cathepsin S, human

2 Cited Publications

Cat. No.: HY-E70226

CAS No.: 71965-46-3

Synonyms: CTSS

Target:

Cathepsin Elastase TGF-beta/Smad Protease Activated Receptor (PAR) Sirtuin NF-κB

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Human Cathepsin S (CTSS) is a cysteine protease with elastinolytic activity. Human Cathepsin S is inhibited by cysteine protease inhibitors such as E-64 (HY-15282) and cystatin C. Human Cathepsin S cleaves substrates including elastin, TGF-β1, Myelin basic protein (HY-P1821), PAR2, SIRT1, collagen 18A1, FKN, and MHC-II invariant chain fragments, thereby driving processes such as elastic matrix degradation, TGF-β1 signaling, demyelination, PAR2-mediated calcium mobilization, NF-κB activation, hepatic fibrosis, immune homeostasis regulation, and antigen presentation. Human Cathepsin S can be used in the research of cardiovascular diseases, chronic kidney diseases, autoimmune diseases, tumors, Alzheimer's disease, and obesity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

G36

1 Cited Publications

Cat. No.: HY-103450

CAS No.: 1392487-51-2

Purity: 99.66%

Target:

Estrogen Receptor/ERR

Research Areas:

Endocrinology Cancer

G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC₅₀=112 nM). G-36 is promising for research in the field of cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

TIP 39, Tuberoinfundibular Neuropeptide

1 Cited Publications

Cat. No.: HY-P1852

CAS No.: 277302-47-3

Target:

Adenylate Cyclase PTHR

Research Areas:

Neurological Disease

TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

MLS1547

1 Cited Publications

Cat. No.: HY-128121

CAS No.: 315698-36-3

Purity: 99.94%

Target:

Dopamine Receptor

Research Areas:

Neurological Disease

MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (K_i=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC₅₀=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R (IC₅₀=9.9 μM) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

5,6-Epoxyeicosatrienoic acid

1 Cited Publications

Cat. No.: HY-132184

CAS No.: 87173-80-6

Purity: ≥99.0%

Synonyms: 5,6-EET; (±)5,6-EpETrE

Target:

Adrenergic Receptor Calcium Channel

Research Areas:

Endocrinology

5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC₅₀=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2.

Compare

loading...