177 Results for "

Cell death pathways

" in MedChemExpress (MCE) Product Catalog:
Products (177)

177 Results for "Cell death pathways" in MCE Product Catalog:

26
Z-VAD
Z-VAD
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26 Publications Verification
Cat. No.: HY-164388
CAS No.: 162852-62-2
Target:  

Caspase Apoptosis Autophagy Necroptosis

Research Areas:  

Cardiovascular Disease Cancer

Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .
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20
Rolipram
Rolipram
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20 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
Target:  

Bacterial HIV Phosphodiesterase (PDE) Epigenetic Reader Domain Amyloid-β

Research Areas:  

Infection Neurological Disease Cancer

Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
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14
4-Hydroperoxy cyclophosphamide
4-Hydroperoxy cyclophosphamide
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14 Cited Publications
Cat. No.: HY-117433
CAS No.: 39800-16-3
Purity:  ≥98.0%
Target:  

DNA Alkylator/Crosslinker Apoptosis Reactive Oxygen Species (ROS) Drug Metabolite

Research Areas:  

Inflammation/Immunology

4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases .
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12
Raptinal
Raptinal
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12 Cited Publications
Cat. No.: HY-121320
CAS No.: 1176-09-6
Purity:  ≥98.0%
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9 .
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11
Genistin
Genistin
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11 Cited Publications
Cat. No.: HY-N0595
CAS No.: 529-59-9
Synonyms: Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside
Category:  

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