10

Ac-CoA Synthase-IN-1

10 Publications Verification

Cat. No.: HY-104032

CAS No.: 508186-14-9

Purity: 99.70%

Target:

RSV

Research Areas:

Infection Metabolic Disease

Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC₅₀ of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .

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10

Mevastatin

10 Publications Verification

Cat. No.: HY-17408

CAS No.: 73573-88-3

Synonyms: Compactin; ML236B

Category:

Cardiovascular Disease Infection Natural Products Microorganisms Neurological Disease Metabolic Disease Disease Research Fields

Target:

HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic

Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

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6

GSK2194069

6 Cited Publications

Cat. No.: HY-12325

CAS No.: 1332331-08-4

Purity: 99.80%

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Cancer

GSK2194069 is a potent inhibitor of β-ketoyl reductase (KR) of fatty acid synthase (FASN), with an IC₅₀ value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC₅₀ or K_i values of 4.8 nM and 5.6 nM, respectively .

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1

ACSL1 Protein, Human (His)

1 Cited Publications

Cat. No.: HY-P704210

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: ACSL1; Lignoceroyl-CoA synthase; Prev. FACL2; Palmitoyl-CoA Ligase 1; LACS2; Palmitoyl-CoA Ligase 2; LACS1; Acyl-CoA Synthetase 1; FACL1; Phytanate--CoA Ligase; LACS; LACS 1; ACS1; LACS 2; Fatty-Acid-Coenzyme A Ligase, Long-Chain 2; Fatty-Acid-Coenzyme A

Species:

Human

Source:

E. coli

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Hymeglusin

Cat. No.: HY-117430

CAS No.: 29066-42-0

Purity: 99.30%

Synonyms: F-244; 1233A; L-659699

Target:

Flavivirus Dengue Virus Antibiotic

Research Areas:

Infection Metabolic Disease Cancer

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC₅₀ = 0.12 μM). Hymeglusin covalently modifies the active Cys ¹²⁹ residue of the enzyme .

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Citrate synthase

Cat. No.: HY-P2739

CAS No.: 9027-96-7

Target:

Endogenous Metabolite

Research Areas:

Others

Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .

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DL-β-Hydroxybutyryl coenzyme A lithium

Cat. No.: HY-134426

CAS No.: 103404-51-9

Purity: 98%

DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase .

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Crotonyl-CoA

Cat. No.: HY-141466

CAS No.: 992-67-6

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Histone Acetyltransferase

Crotonyl-CoA, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA can be used for the research of LPS-induced inflammatory response .

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Crotonyl-CoA tetrasodium

Cat. No.: HY-141466A

Purity: 97.85%

Target:

Endogenous Metabolite Histone Acetyltransferase

Research Areas:

Infection Metabolic Disease Inflammation/Immunology

Crotonyl-CoA tetrasodium, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA tetrasodium is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA tetrasodium acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA tetrasodium regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA tetrasodium serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA tetrasodium can be used for the research of LPS-induced inflammatory response .

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GSK837149A

Cat. No.: HY-117769

CAS No.: 13616-29-0

Purity: ≥99.0%

Target:

Fatty Acid Synthase (FASN)

Research Areas:

Metabolic Disease

GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (K_i=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer .

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6,9,12,15,18-Heneicosapentaenoic acid

Cat. No.: HY-141469

CAS No.: 65919-53-1

Synonyms: HPA; Heneicosapentaenoic acid methyl ester

Category:

Animals Lipids

Target:

PGE synthase Lipoxygenase

6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer .

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Glutaryl coenzyme A lithium

Cat. No.: HY-141474

CAS No.: 103192-48-9

Purity: 99.00%

Target:

Endogenous Metabolite Mitochondrial Metabolism

Research Areas:

Neurological Disease Metabolic Disease

Glutaryl coenzyme A lithium is an endogenous metabolite. Glutaryl coenzyme A lithium acts on the E2k subunit to inhibit KGDHc. It serves as a substrate for the reverse reaction of E2k and does not affect the E1k or E3 subunits of KGDHc. Glutaryl coenzyme A lithium exhibits weak inhibitory activity against citrate synthase. It can be used in research on glutaryl-CoA dehydrogenase deficiency (type I glutaric acidemia) .

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