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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Complex I-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Complex I-IN-1" in MCE Product Catalog:
Cat. No.: HY-184440
CAS No.: 3080323-62-9
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Complex I-IN-1 is a novel fungicide that acts as a mitochondrial complex I inhibitor. Complex I-IN-1 regulates oxidoreductase activity, glycolysis/gluconeogenesis, methionine metabolism, and the MAPK signaling pathway in Blumeria graminis. Complex I-IN-1 is applicable to research related to wheat powdery mildew .
2
2 Cited Publications
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MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes .
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BAY-179, a chemical probe, is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively .
Cat. No.: HY-N10612
CAS No.: 26577-85-5
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Natural Products Plant Compositae/Asteraceae Extract Petasites japonicus (Sieb. et Zucc.) Maxim. Extract
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Cat. No.: HY-184282
Mitochondrial complex I-IN-1 is a Mitochondrial complex I inhibitor. Mitochondrial complex I-IN-1 activates the AMPK signaling pathway, inhibits the downstream mTOR/S6 axis, induces Apoptosis and triggers Autophagy. Mitochondrial complex I-IN-1 can be used for the research of non-small cell lung cancer .
Synonyms: ARC 111
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Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .
Cat. No.: HY-174252
CAS No.: 3016396-78-1
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HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research .
Cat. No.: HY-P4044
CAS No.: 168417-72-9
Cat. No.: HY-W035150
CAS No.: 578743-87-0
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Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) (Compound 1) is a NHC copper complex and anticancer agent. Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) exhibits cytotoxic activity against breast cancer, lung cancer, melanoma, and glioma cells .
Cat. No.: HY-184379
CAS No.: 2358714-71-1
SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
