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50 Results for "

Cryptococcus neoformans

" in MedChemExpress (MCE) Product Catalog:

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Pedalitin

2 Cited Publications

Cat. No.: HY-N3101

CAS No.: 22384-63-0

Category:

Flavonoids Flavones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Endocrinology

Target:

Endogenous Metabolite Tyrosinase Glycosidase Xanthine Oxidase Glutathione Peroxidase Fungal

Pedalitin is a tyrosinase and α-glucosidase inhibitor with IC₅₀ values of 0.28 mM and 0.29 mM, respectively, and can be isolated and extracted from Rabdosia serra. Pedalitin is a xanthine oxidase (Xanthine Oxidase) (IC₅₀ = 3.7 µM) and myeloperoxidase (MPO) (IC₅₀ = 3.8 nM) inhibitor. Pedalitin ameliorates NAFLD by downregulating the EGFR/IRS1/AKT1/FOXO1 signaling pathway and related inflammatory and lipid metabolism factors. Pedalitin reduces the risk of urinary tract infection and stones by inhibiting the expression of the urease UreC gene in Proteus mirabilis. Pedalitin also exhibits antifungal activity, with a MIC of 3.9 mg/L against Cryptococcus neoformans. Pedalitin can be used for research on non-alcoholic fatty liver disease, chronic kidney disease, kidney stones, cryptococcosis, and abdominal pain .

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T-2307

Cat. No.: HY-114220

CAS No.: 873546-31-7

Purity: 98.41%

Target:

Fungal Mitochondrial Metabolism

Research Areas:

Infection

T-2307 is an antifungal agent with blood-brain barrier penetration. T-2307 exhibits broad-spectrum antifungal activity against Candida species, including echinocandin-resistant strains, Cryptococcus neoformans, Cryptococcus gattii, and some Aspergillus species. T-2307 selectively targets fungal mitochondrial respiratory chain complexes III and IV, causing collapse of the fungal mitochondrial membrane potential and exerting fungicidal or fungistatic effects. T-2307 can be used in research related to fungal infections such as invasive candidiasis, cryptococcosis, and aspergillosis .

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FAICAR

Cat. No.: HY-133157

CAS No.: 13018-54-7

Purity: 85.00%

Synonyms: 5-Formamidoimidazole-4-carboxamide ribotide

Category:

Microorganisms Ketones, Aldehydes, Acids

Target:

DNA/RNA Synthesis

FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection .

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