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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
D2R agonist
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "D2R agonist" in MCE Product Catalog:
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3 Cited Publications
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UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity .
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3 Cited Publications
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UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC50 <10 nM for β-arrestin-2 recruitment to D2 receptors. UNC9994 is simultaneously partial agonists of β-arrestin-2 translocation and antagonists of Gi-regulated cAMP production. Antipsychotic Activity .
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1 Cited Publications
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MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R (IC50=9.9 μM) .
Cat. No.: HY-P3294
CAS No.: 778630-77-6
Synonyms: BIM-23A760; TBR-760
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Cat. No.: HY-116445
CAS No.: 1354030-19-5
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UNC9975 is a D2R agonist that displays signaling bias via β-arrestin–ergic signaling and a simultaneously antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9975 can be utilized in antipsychotic research .
Cat. No.: HY-179713
CAS No.: 3028684-07-0
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D2R/D3R/5-HT1AR agonist 1 (compound 22b) is an orally active triple-target D2R/D3R/5-HT1AR agonist with EC50 values of 1.29, 1.05 and 153.5 nM. D2R/D3R/5-HT1AR agonist 1 can improve the behavioral disorders induced by MPTP (HY-W114750) and exerts anti-depression effect. D2R/D3R/5-HT1AR agonist 1 can be used for the research of Parkinson's disease and depression .
Cat. No.: HY-47412
CAS No.: 791778-53-5
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Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway .
Cat. No.: HY-111385R
CAS No.: 2108826-33-9
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UNC9994 hydrochloride (Standard) is the analytical standard of UNC9994 (hydrochloride) (HY-111385). This product is intended for research and analytical applications. UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity .
Cat. No.: HY-187696
CAS No.: 2349365-88-2
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MS1768 is a G protein-biased, partial, and selective D2R agonist. MS1768 selectively activates the Gi/o signaling pathway rather than recruiting β-arrestin2. MS1768 inhibits hyperkinesia. MS1768 can be used in studies of hyperkinesia .
Cat. No.: HY-123828
CAS No.: 389080-71-1
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MLS6585 is a selective D1 dopamine receptor (D1R) positive allosteric modulator that enhances Dopamine (HY-B0451)-stimulated G protein/β-arrestin signaling and affinity without intrinsic D1R agonist activity. MLS6585 is inactive at D2R, D3R, D4R, and β2-adrenergic receptors. MLS6585 partially restores signaling of loss-of-function DRD1 variants and enhances responses to multiple agonists .
Cat. No.: HY-189719
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EA-Ri-153 is a selective D3R agonist. EA-Ri-153 has a Ki = 2.8 nM and pEC50 = 8.9 for D3R, and a Ki = 1.2 μM for D2R, with a D3/D2 selectivity ratio of 435-fold. EA-Ri-153 has a Ki = 2.5 μM for 5-HT1AR and a Ki = 22.8 μM for 5-HT2AR. EA-Ri-153 can be used for research on diseases related to the dopamine D3 receptor subtype .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
