34

A 922500

34 Publications Verification

Cat. No.: HY-10038

CAS No.: 959122-11-3

Purity: 99.33%

Synonyms: DGAT-1 Inhibitor 4a

Target:

Acyltransferase

Research Areas:

Metabolic Disease

A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of 9 and 22 nM against human and mouse DGAT-1, respectively.

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15

T863

15 Cited Publications

Cat. No.: HY-32219

CAS No.: 701232-20-4

Target:

Acyltransferase

Research Areas:

Metabolic Disease

T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC₅₀ of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells ^[1] .

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9

PF-04620110

9 Cited Publications

Cat. No.: HY-13009

CAS No.: 1109276-89-2

Purity: 99.60%

Target:

Acyltransferase

Research Areas:

Metabolic Disease

PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC₅₀ of 19 nM ^[1].

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3

DGAT1-IN-1

3 Cited Publications

Cat. No.: HY-12425

CAS No.: 1449779-49-0

Purity: ≥98.0%

Target:

Acyltransferase

Research Areas:

Metabolic Disease

DGAT1-IN-1 is a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor with a human IC₅₀ of <10 nM and a mouse IC₅₀ of <50 nM. DGAT1-IN-1 is applicable to the research of obesity-related diseases, type 2 diabetes and diabetes-related diseases ^[1].

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2

DGAT-1 inhibitor 2

2 Cited Publications

Cat. No.: HY-50670

CAS No.: 942999-61-3

Target:

Carnitine Palmitoyltransferase (CPT) Acyltransferase Reactive Oxygen Species (ROS) HSP PERK

Research Areas:

Metabolic Disease

DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC₅₀ values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity ^[1] .

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2

Pradigastat

2 Cited Publications

Cat. No.: HY-16278

CAS No.: 956136-95-1

Synonyms: LCQ-908

Target:

Acyltransferase BCRP OAT

Research Areas:

Infection Metabolic Disease

Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro ^[1] .

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2

AZD3988

2 Cited Publications

Cat. No.: HY-50861

CAS No.: 892489-52-0

Target:

Acyltransferase

Research Areas:

Metabolic Disease

AZD3988 is an orally active diacylglycerol acyl transferase-1 (DGAT-1) inhibitor. AZD3988 has excellent DGAT-1 (human) potency with an IC₅₀ value of 0. 6 nM. AZD3988 can be used for the research of metabolic diseases such as diabetes, obesity ^[1].

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1

AZD7687

1 Cited Publications

Cat. No.: HY-15497

CAS No.: 1166827-44-6

Purity: 99.80%

Target:

Acyltransferase

Research Areas:

Metabolic Disease

AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC₅₀ of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research ^[1] .

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1,2-Dioleoyl-sn-glycerol

Cat. No.: HY-141572

CAS No.: 24529-88-2

Purity: 99.96%

Synonyms: sn-1,2-Dioleoylglycerol; 18:1/18:1-DG

1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm ^[1] .

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DGAT1 Human Pre-designed siRNA Set A

Cat. No.: HY-RS03710

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

DGAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DGAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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DGAT1-IN-3

Cat. No.: HY-16434

CAS No.: 939375-07-2

Target:

Acyltransferase

Research Areas:

Metabolic Disease

DGAT1-IN-3 is a potent, selective and orally bioavailable inhibitor of DGAT-1, with IC₅₀s of 38 nM for human DGAT-1 and 120 nM for rat DGAT-1. DGAT1-IN-3 could be used to research of obesity, dyslipidemia, and metabolic syndrome ^[1] .

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ABT-046

Cat. No.: HY-15197

CAS No.: 1031336-60-3

Purity: 98.57%

Target:

Acyltransferase

Research Areas:

Metabolic Disease

ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of both 8 nM against human and mouse DGAT-1 ^[1].

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