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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
298 Results for "
EPI
" in MedChemExpress (MCE) Product Catalog:
Products (298)
298 Results for "EPI" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: (-)-EPIcatechol; EPIcatechin; EPI-Catechin
Category:
Anti-aging Endogenous metabolite Theaceae Extract Plant Flavonoids Sunscreen Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer
Target:
4
Category:
Plant Taxus chinensis (Pilger) Rehd. Extract Taxaceae Extract Terpenoids Diterpenoids Disease Research Fields Cancer
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2
Category:
Natural Products Other Diseases Brassinolide Microorganism Phytohormone Disease Research Fields Agricultural Research
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1
1 Cited Publications
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EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC) .
1
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1
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1
1 Cited Publications
Cat. No.: HY-P77227
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI; EPI; Prev. LACI; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); Extrinsic Pathway Inhibitor; Lipoprotein-Associated Coagulation Inhibitor; TFPI1; Anti-Convertin; Tissue Factor Pathway Inhibitor; TFI
Species:
Human
Source:
HEK293
Target:
Research Areas:
EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .
Cat. No.: HY-16772
CAS No.: 1213269-98-7
Synonyms: α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
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EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .
Cat. No.: HY-P99049
CAS No.: 2305607-45-6
Synonyms: APX005M; APX005M; EPI-0050
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Synonyms: EPI-002
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Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC) .
Synonyms: EPI-506
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Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .
Synonyms: (-)-EPIcatechol(Standard); EPIcatechin(Standard); EPI-Catechin (Standard)
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Research Areas:
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .
Cat. No.: HY-77572
CAS No.: 78454-17-8
Synonyms: 7-EPI-10-deacetyltaxol; 10-Deacetyl-7-EPIpaclitaxel
Cat. No.: HY-N10379
CAS No.: 132923-06-9
Target:
Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related
Research Areas:
19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .
Synonyms: 27-Deoxyactein
Category:
Triterpenes Plant Terpenoids Metabolic Disease Other Families Extract Disease Research Fields
Target:
Synonyms: EPIcholecalciferol
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells .
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6-epi Doxycycline is an epimer of Doxycycline (HY-N0565), produced as a degradation product through the isomerization of Doxycycline under abnormal conditions (such as high temperature, pH changes, or humidity). 6-epi Doxycycline is commonly used for the detection and analysis of impurity content in pharmaceutical formulations .
Cat. No.: HY-N10343
CAS No.: 19237-18-4
Category:
Natural Products Plant Other Diseases Glucosinolates Other Families Extract Disease Research Fields
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
