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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
FL-47
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "FL-47" in MCE Product Catalog:
Cat. No.: HY-187395
CAS No.: 3083133-71-2
Research Areas:
FL47 is a FEM1B modulator with an IC50 of 0.96 μM against human FEM1B. FL47 binds to FEM1B via a dual-site interaction, forming non-covalent interactions at site A while covalently modifying Cys186 at site C. FL47 stabilizes FNIP1 in a FEM1B-dependent manner in cells. FL47 can be used in studies related to root-knot nematode infections .
Cat. No.: HY-187396
Target:
Research Areas:
FD1-C10-CB is a PROTAC degrader targeting the BRD4 protein. FD1-C10-CB binds to FEM1B to form a ternary complex with BRD4, achieving FEM1B-dependent degradation of BRD4 via the ubiquitin-proteasome system. FD1-C10-CB binds to CD36 to mediate endocytic cellular delivery, thereby enhancing its degrading activity. FD1-C10-CB mediates protein degradation through the Cullin-dependent ubiquitin-proteasome pathway, rather than the lysosomal autophagy pathway. FD1-C10-CB induces a decrease in BRD4 protein levels, and its degrading activity is competitively inhibited by FL47 or JQ1. FD1-C10-CB can be used in the research of breast cancer and osteosarcoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
