Factor xa | MedChemExpress (MCE) Life Science Reagents

Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.

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18

Rivaroxaban

18 Cited Publications

Cat. No.: HY-50903

CAS No.: 366789-02-8

Synonyms: BAY 59-7939

Target:

Research Areas:

Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC₅₀ 0.7 nM; K_i 0.4 nM) .

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14

Apixaban

14 Cited Publications

Cat. No.: HY-50667

CAS No.: 503612-47-3

Synonyms: BMS-562247-01

Target:

Research Areas:

Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

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10

Edoxaban

10 Cited Publications

Cat. No.: HY-10264

CAS No.: 480449-70-5

Purity: 99.81%

Synonyms: DU-176

Target:

Factor Xa Thrombin

Research Areas:

Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_i values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research .

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10

Edoxaban tosylate

10 Cited Publications

Cat. No.: HY-10264A

CAS No.: 480449-71-6

Purity: 99.84%

Synonyms: DU-176b

Target:

Factor Xa Thrombin

Research Areas:

Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_is of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research .

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10

Edoxaban tosylate monohydrate

10 Cited Publications

Cat. No.: HY-10264B

CAS No.: 1229194-11-9

Purity: 99.97%

Synonyms: DU-176b monohydrate

Target:

Factor Xa Thrombin

Research Areas:

Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_is of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research .

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5

Betrixaban

5 Cited Publications

Cat. No.: HY-10268

CAS No.: 330942-05-7

Purity: 98.02%

Synonyms: PRT054021

Target:

Research Areas:

Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

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5

Betrixaban maleate

5 Cited Publications

Cat. No.: HY-10268A

CAS No.: 936539-80-9

Purity: 99.78%

Synonyms: PRT054021 maleate

Target:

Research Areas:

Betrixaban (PRT054021) maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban maleate shows antithrombotic effect .

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4

Fondaparinux sodium

4 Cited Publications

Cat. No.: HY-B0597

CAS No.: 114870-03-0

Synonyms: Fondaparin sodium; SR-90107A

Target:

Research Areas:

Thrombin Factor Xa Autophagy

Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

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4

Gabexate mesylate

4 Cited Publications

Cat. No.: HY-B0385

CAS No.: 56974-61-9

Synonyms: FOY

Target:

Proteasome Factor Xa

Research Areas:

Inflammation/Immunology

Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

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3

Heparin sodium salt (MW 15kDa)

3 Cited Publications

Cat. No.: HY-17567C

CAS No.: 9041-08-1

Synonyms: Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)

Target:

Research Areas:

Factor Xa Thrombin SARS-CoV

Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa .

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2

Rivaroxaban-d4

2 Cited Publications

Cat. No.: HY-50903S

CAS No.: 1132681-38-9

Synonyms: BAY 59-7939-d₄

Rivaroxaban-d₄ (BAY 59-7939-d₄) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC₅₀ 0.7 nM; K_i 0.4 nM) .

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1

Enoxaparin

1 Cited Publications

Cat. No.: HY-109509

CAS No.: 679809-58-6

Synonyms: PK 10169; Enoxaparin sodium

Target:

Research Areas:

Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .

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1

ARC19499 sodium

1 Cited Publications

Cat. No.: HY-153480A

Purity: 93.65%

Synonyms: BAX499 sodium

Target:

Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)

Research Areas:

Others

ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

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1

5-R-Rivaroxaban

1 Cited Publications

Cat. No.: HY-76948

CAS No.: 865479-71-6

Target:

Research Areas: