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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
Fluorescence assay
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "Fluorescence assay" in MCE Product Catalog:
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Lissamine rhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Lissamine rhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays .
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3 Cited Publications
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hPGDS-IN-1 (Compound 2 ) is an hPGDS inhibitor with an IC50 of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons .
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2 Cited Publications
Cat. No.: HY-15941
CAS No.: 27072-45-3
Synonyms: Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
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2 Cited Publications
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GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
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2 Cited Publications
Cat. No.: HY-18717
CAS No.: 1429176-69-1
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Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.
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6-TAMRA (6-Carboxytetramethylrhodamine) is a fluorescent dye. 6-TAMRA is often used in combination with 6-FAM (HY-66021) as an acceptor or fluorescence quencher for fluorescence resonance energy transfer (FRET) in biochemical studies such as potassium ion detection and ribonuclease activity assays .
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1 Cited Publications
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GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
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1 Cited Publications
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1 Cited Publications
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Calcein Blue AM is a cell staining agent. Calcein Blue AM serves as a substrate for intracellular esterases, which hydrolyze its acetoxymethyl (AM) ester group to convert the non-fluorescent reagent into fluorescent Calcein Blue. Calcein Blue AM passively penetrates the plasma membrane of both live and dead cells; it is converted into a polar fluorescent product and retained in the cytoplasm of live cells, whereas dead cells cannot retain the dye. Calcein Blue AM exhibits significant dye leakage, and its fluorescence intensity gradually decreases over time. Calcein Blue AM can be used for endpoint-based cell viability assays and short-term cell tracking experiments with a duration of no more than 4 hours.
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1 Cited Publications
Cat. No.: HY-D1423
CAS No.: 68654-25-1
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Dibromobimane is a Fluorescent dye and probe that can be used for the detection of intracellular reduced glutathione and the analysis of spatial proximity of closely adjacent cysteine thiol groups. Dibromobimane activates fluorescence through binding to thiol groups; its excitation/emission wavelengths are Ex/Em = 393/477 nm for glutathione detection, and Ex/Em = 385/477 nm for cysteine thiol cross-linking. Dibromobimane uses two equivalent bromomethyl groups to cross-link cysteine thiolates with a distance ranging from 3-6 Å. Dibromobimane can be applied to 96-well microplate-based high-throughput assays for labeling intracellular glutathione, and its fluorescence signal is normalized against nuclear staining results to eliminate the impact of cell density .
Cat. No.: HY-175686
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E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9 μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs .
Cat. No.: HY-163385
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ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA .
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BODIPY FL thalidomide is a high-affinity and selective human cereblon (CRBN)-targeting fluorescent probe with a Kd of 3.6 nM. BODIPY FL thalidomide enables use as a probe in time-resolved fluorescence resonance energy transfer (TR-FRET) binding assays for cereblon ligands. BODIPY FL thalidomide supports development of highly sensitive, selective, stable cereblon TR-FRET binding assays (Ex/Em = 502/510 nm) .
Cat. No.: HY-P5908F
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BMS-1001 is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 exhibits low-toxicity in cells. The IC50 value of BMS-1001 in a homogeneous time-resolved fluorescence (HTRF) binding assay is 2.25 nM .
Cat. No.: HY-D2017
CAS No.: 1251752-59-6
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ATTO 550 is a fluorescent dye in the orange spectral range, commonly used as a fluorescent probe for the labeling and detection of biomolecules. ATTO 550 can be used to label nucleic acids, proteins, and small molecules, and is widely applied in super-resolution imaging, flow cytometry, fluorescence lifetime imaging (FLIM), fluorescence resonance energy transfer (FRET), and fluorescence intensity-based cell uptake and binding assays. The excitation/emission wavelengths of ATTO 550 are approximately Ex/Em = 554/576 nm .
Cat. No.: HY-169929
CAS No.: 3058906-46-7
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KCC2 potentiators-1 is a KCC2 potentiator with an EC50 of less than 0.1 μM in NG-108 cells. KCC2 potentiators-1 exhibits potentiating activity in neuronal cells via fluorescence-based assays. KCC2 potentiators-1 can be used for the research of neurological disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
