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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
GABA uptake
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "GABA uptake" in MCE Product Catalog:
16
Target:
Research Areas:
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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16 Publications Verification
Cat. No.: HY-B0211A
CAS No.: 850608-87-6
Synonyms: PK 26124 hydrochloride
Target:
Research Areas:
Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
2
2 Cited Publications
Synonyms: (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine
Target:
Research Areas:
Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM .
1
1 Cited Publications
Cat. No.: HY-16974
CAS No.: 1093861-60-9
Target:
Research Areas:
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod .
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Arecaidine hydrobromide is a GABA transport system inhibitor. Arecaidine hydrobromide inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine hydrobromide inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine hydrobromide inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine hydrobromide can be used in research related to neurological diseases .
Synonyms: trans-4-Aminocrotonic acid
Target:
Research Areas:
TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons .
Cat. No.: HY-W067716
CAS No.: 59981-63-4
Synonyms: (S)-Spinacine
Target:
Target:
Research Areas:
NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
Cat. No.: HY-124030
CAS No.: 70030-11-4
Target:
Research Areas:
3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [ 3H]GABA uptake .
Cat. No.: HY-W103105
CAS No.: 53786-28-0
Target:
Research Areas:
R 29676 is a putative metabolite of Halopemide (HY-119093). R 29676 inhibits the binding of sodium-independent GABA to postsynaptic GABA receptors. R 29676 inhibits the binding of benzodiazepines to rat forebrain membranes. R 29676 inhibits sodium-dependent GABA binding to transporters and uptake, as well as Serotonin (HY-B1473A) uptake by rat platelets .
Research Areas:
Riluzole (Standard) is the analytical standard of Riluzole. This product is intended for research and analytical applications. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
Cat. No.: HY-16974R
CAS No.: 1093861-60-9
Research Areas:
Afoxolaner (Standard) is the analytical standard of Afoxolaner. This product is intended for research and analytical applications. Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod .
Cat. No.: HY-W067716R
CAS No.: 59981-63-4
Synonyms: (S)-Spinacine (Standard)
Target:
Cat. No.: HY-B0211S1
Synonyms: PK 26124-13C6
Cat. No.: HY-155238
CAS No.: 1520073-91-9
Target:
Research Areas:
E2730 is a noncompetitive but selective inhibitor of gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with orally available and antiepileptic activity. E2730-mediated GAT1 inhibition is positively correlated with environmental GABA levels and selectively inhibits GAT1-mediated GABA uptake. E2730 (5-50 mg/kg; po) in rat amygdala ignition model, and in mouse cornea ignition (5-50 mg/kg), drug resistance 6Hz-44mA has demonstrated in vivo efficacy in models of psychomotor epilepsy (5-50 mg/kg), fragile X syndrome (2.5-300 mg/kg), and Dravet syndrome (10 mg/kg, 20 mg/kg) .
Cat. No.: HY-W291165
CAS No.: 26908-94-1
Synonyms: D-2,4-Diaminobutyric acid
Target:
Research Areas:
D-DABA is the enantiomeric form of L-DABA. D-DABA is also a weak inhibitor of GABA-T, but which has only one twentieth of the potency of the
L-isomer in inhibiting GABA uptake.
Cat. No.: HY-W103105R
CAS No.: 53786-28-0
R 29676 (Standard) is the analytical standard of R 29676 (HY-W103105). This product is intended for research and analytical applications. R 29676 is a putative metabolite of Halopemide (HY-119093). R 29676 inhibits the binding of sodium-independent GABA to postsynaptic GABA receptors. R 29676 inhibits the binding of benzodiazepines to rat forebrain membranes. R 29676 inhibits sodium-dependent GABA binding to transporters and uptake, as well as Serotonin (HY-B1473A) uptake by rat platelets .
Cat. No.: HY-129464
CAS No.: 127586-66-7
Target:
Research Areas:
NO-711ME is a prodrug of NO-711. NO-711 is a potent and selective GABA uptake inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
