42 Results for "

GGT

" in MedChemExpress (MCE) Product Catalog:
Products (42)

42 Results for "GGT" in MCE Product Catalog:

7
GGsTop
GGsTop
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7 Publications Verification
Cat. No.: HY-108467
CAS No.: 926281-37-0
Synonyms: Nahlsgen
Target:  

γ-Glutamyl Transferase (GGT)

Research Areas:  

Cardiovascular Disease

GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M -1 s -1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model .
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7
GPNA hydrochloride
GPNA hydrochloride
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7 Publications Verification
Cat. No.: HY-W011391
CAS No.: 67953-08-6
Target:  

Apoptosis ASCT

Research Areas:  

Cancer

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na +-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na +-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .
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5
ODN TTAGGG
ODN TTAGGG
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5 Cited Publications
Cat. No.: HY-150751
CAS No.: 1801724-76-4
Purity:  93.80%
Synonyms: ODN A151
Target:  

Toll-like Receptor (TLR) AIM2 Pyroptosis Interleukin Related

Research Areas:  

Inflammation/Immunology

ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus . ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.
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3
AS 1411
AS 1411
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3 Cited Publications
Cat. No.: HY-147081
CAS No.: 301636-59-9
Purity:  99.52%
Synonyms: AGRO-100
Target:  

Histone Methyltransferase Bcl-2 Family

Research Areas:  

Cancer

AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
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2
Acivicin
Acivicin
0 Images
2 Cited Publications
Cat. No.: HY-W016586
CAS No.: 42228-92-2
Synonyms: AT-125; U-42126
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Parasite γ-Glutamyl Transferase (GGT)

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
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2
Acivicin hydrochloride
Acivicin hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-W016586A
CAS No.: 161922-40-3
Synonyms: AT-125 hydrochloride; U-42126 hydrochloride
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Parasite

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
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1
FGTI-2734
FGTI-2734
0 Images
1 Cited Publications
Cat. No.: HY-128350
CAS No.: 1247018-19-4
Purity:  99.85%
Target:  

Farnesyl Transferase

Research Areas:  

Cancer

FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
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1
FGTI-2734 mesylate
FGTI-2734 mesylate
0 Images
1 Cited Publications
Cat. No.: HY-128350A
CAS No.: 2702297-24-1
Purity:  99.65%
Target:  

Farnesyl Transferase γ-Glutamyl Transferase (GGT)

Research Areas:  

Cancer

FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
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1
γ-glutamyltransferase, Porcine kidney
γ-glutamyltransferase, Porcine kidney
0 Images
1 Cited Publications
Cat. No.: HY-P2997
CAS No.: 9046-27-9
Synonyms: GGT, Porcine kidney
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

γ-glutamyltransferase, Porcine kidney (GGT, Porcine kidney) is an enzyme located on the outer surface of the cell membrane. γ-glutamyltransferase, Porcine kidney maintains the physiological concentration of cytoplasmic glutathione and the cell's defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. γ-glutamyltransferase, Porcine kidney is used for pancreatic cancer research .
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1
Aprinocarsen sodium
Aprinocarsen sodium
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1 Cited Publications
Cat. No.: HY-148413
CAS No.: 331257-53-5
Purity:  90.35%
Synonyms: ISIS 3521 sodium
Target:  

PKC

Research Areas:  

Cancer

Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .
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1
GGT1 Protein, Human (HEK293, His)
GGT1 Protein, Human (HEK293, His)
0 Images
1 Cited Publications
Cat. No.: HY-P700729
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GGT1; GGT 1; Prev. GGT; Gamma-Glutamyltranspeptidase; D22S732; Gamma-Glutamyltransferase; D22S672; Glutathione Hydrolase; CD224; CD224 Antigen; Glutathione Hydrolase 1 Proenzyme; GGT1 Protein; Gamma-Glutamyltranspeptidase 1; GGTD; Leukotriene-C4 Hydrolase
Species:  
Human
Source:  
HEK293
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Rovunaptabin
Rovunaptabin
0 Images
Cat. No.: HY-148826
CAS No.: 145563-68-4
Synonyms: ARC 183; BC 007
Target:  

G Protein-coupled Receptor Kinase (GRK)

Research Areas:  

Cardiovascular Disease

Rovunaptabin (ARC 183) is an aptamer, a single-stranded DNA molecule composed of 15 deoxynucleotides. It acts as a broad-spectrum neutralizer of pathogenic G-protein-coupled receptor autoantibodies. Rovunaptabin can be used in research related to cardiomyopathy and pulmonary hypertension .
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ODN 1585
ODN 1585
0 Images
Cat. No.: HY-150725
CAS No.: 386832-46-8
Target:  

IFNAR TNF Receptor

Research Areas:  

Infection Cancer

ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .
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Bepirovirsen
Bepirovirsen
0 Images
Cat. No.: HY-147217
CAS No.: 1403787-62-1
Purity:  97.10%
Synonyms: ISIS 505358
Target:  

HBV

Research Areas:  

Infection

Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen can be used for the research of chronic HBV infection. Bepirovirsen binding site sequence (GCACTTCGCTTCACCTCTGC) .
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L-Glutamic acid γ-(3-carboxy-4-nitroanilide) ammonium salt
L-Glutamic acid γ-(3-carboxy-4-nitroanilide) ammonium salt
0 Images
Cat. No.: HY-15936
CAS No.: 63699-78-5
Synonyms: L-γ-Glutamyl-3-carboxy-4-nitroanilide ammonium salt
L-Glutamic acid γ-(3-carboxy-4-nitroanilide) ammonium salt is a donor substrate of gamma-glutamyltransferase (GGT) that can be used to measure GGT activity .
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Licraside
Licraside
0 Images
Cat. No.: HY-N6987
CAS No.: 29913-71-1
Category:  

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