601

RSL3

601 Publications Verification

Cat. No.: HY-100218A

CAS No.: 1219810-16-8

Purity: 99.90%

Synonyms: (1S,3R)-RSL3

Target:

p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

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65

GCN2iB

65 Cited Publications

Cat. No.: HY-112654

CAS No.: 2183470-12-2

Purity: 99.83%

Target:

Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC₅₀ of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .

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37

iFSP1

37 Cited Publications

Cat. No.: HY-136057

CAS No.: 150651-39-1

Purity: 99.96%

Target:

Ferroptosis Ligands for Target Protein for PROTAC

Research Areas:

Cancer

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

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34

ML-210

34 Cited Publications

Cat. No.: HY-100003

CAS No.: 1360705-96-9

Purity: 99.66%

Target:

Glutathione Peroxidase Ferroptosis

Research Areas:

Cancer

ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

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29

FIN56

29 Cited Publications

Cat. No.: HY-103087

CAS No.: 1083162-61-1

Purity: 98.03%

Target:

Ferroptosis

Research Areas:

Others

FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

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25

GPX4 Antibody (YA399)

25 Cited Publications

Cat. No.: HY-P80450

Synonyms: Phospholipid hydroperoxide glutathione peroxidase GPx4, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPx4

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, FC

Reactivity:

Human, Mouse, Rat

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19

ML162

19 Cited Publications

Cat. No.: HY-100002

CAS No.: 1035072-16-2

Purity: 99.46%

Target:

Glutathione Peroxidase Ferroptosis

Research Areas:

Cancer

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

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16

FINO2

16 Cited Publications

Cat. No.: HY-129457

CAS No.: 869298-31-7

Purity: ≥98.0%

Target:

Ferroptosis

Research Areas:

Cancer

FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

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14

DOPE

14 Cited Publications

Cat. No.: HY-112005

CAS No.: 4004-05-1

Purity: 98.80%

Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Target:

Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase

Research Areas:

Inflammation/Immunology Cancer

DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease ^[4].

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8

PKUMDL-LC-101-D04

8 Cited Publications

Cat. No.: HY-115627

CAS No.: 2143896-83-5

Purity: 99.94%

Synonyms: GPx4-Activator-1d4

Target:

Glutathione Peroxidase

Research Areas:

Inflammation/Immunology

PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

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7

JKE-1674

7 Cited Publications

Cat. No.: HY-138153

CAS No.: 2421119-60-8

Purity: 99.54%

Target:

Glutathione Peroxidase Ferroptosis

Research Areas:

Cancer

JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

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5

GPX4 Antibody

5 Cited Publications

Cat. No.: HY-P80692

Synonyms: Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4

Host:

Rabbit

Application:

WB, IHC-F, IHC-P, ICC/IF

Reactivity:

Human, Mouse, Rat

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4

GPX4-IN-3

4 Cited Publications

Cat. No.: HY-141809

CAS No.: 2761004-85-5

Purity: 99.83%

Target:

Glutathione Peroxidase Ferroptosis

Research Areas:

Cancer

GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

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4

Seratrodast

4 Cited Publications

Cat. No.: HY-B0774

CAS No.: 112665-43-7

Synonyms: AA 2414

Target:

Ferroptosis JNK MDM-2/p53 Prostaglandin Receptor Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Inflammation/Immunology Endocrinology Cancer

Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity .

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