128

128 Publications Verification

Category:

Cardiovascular Disease Natural Products Neurological Disease Plants Other Families Extract Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms Animals Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite HSP

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .

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128

Palmitic acid sodium

128 Publications Verification

Cat. No.: HY-N0830B

CAS No.: 408-35-5

Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

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54

VER-155008

54 Cited Publications

Cat. No.: HY-10941

CAS No.: 1134156-31-2

Purity: 99.91%

Target:

HSP Autophagy

Research Areas:

Neurological Disease Cancer

VER-155008 is an inhibitor of Hsp70, with IC₅₀s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a K_d of 0.3 μM for Hsp70.

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34

HA15

34 Cited Publications

Cat. No.: HY-100437

CAS No.: 1609402-14-3

Purity: 99.98%

Target:

HSP Autophagy Apoptosis

Research Areas:

Cancer

HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity .

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9

Pimitespib

9 Cited Publications

Cat. No.: HY-15785

CAS No.: 1260533-36-5

Purity: 98.79%

Synonyms: TAS-116

Target:

HSP

Research Areas:

Cancer

Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (K_is of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94 . Pimitespib demonstrates less ocular toxicity .

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7

BiP inducer X

7 Cited Publications

Cat. No.: HY-110188

CAS No.: 101714-41-4

Purity: 99.88%

Target:

Apoptosis

Research Areas:

Neurological Disease

BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress .

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5

Grp94 Inhibitor-1

5 Cited Publications

Cat. No.: HY-112910

CAS No.: 2234897-35-7

Purity: 98.72%

Target:

HSP

Research Areas:

Inflammation/Immunology Cancer

Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC₅₀ value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α .

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5

Retaspimycin Hydrochloride

5 Cited Publications

Cat. No.: HY-10210

CAS No.: 857402-63-2

Purity: 96.16%

Synonyms: IPI-504

Target:

HSP

Research Areas:

Cancer

Retaspimycin Hydrochloride is a potent inhibitor of Hsp90 with EC₅₀s of 119 nM for both Hsp90 and Grp9.

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5

YUM70

5 Cited Publications

Cat. No.: HY-138364

CAS No.: 423145-35-1

Purity: 98.01%

Target:

HSP Apoptosis

Research Areas:

Cancer

YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model .

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5

VER-82576

5 Cited Publications

Cat. No.: HY-10942

CAS No.: 847559-80-2

Purity: 98.76%

Synonyms: NVP-BEP800

Target:

HSP

Research Areas:

Cancer

VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC₅₀ of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC₅₀s of 4.1 and 5.5 μM, respectively.

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4

NVP-HSP990

4 Cited Publications

Cat. No.: HY-15190

CAS No.: 934343-74-5

Purity: 99.49%

Synonyms: HSP-990

Target:

HSP Apoptosis

Research Areas:

Cancer

NVP-HSP990 is a potent, selective and orally active Hsp90 inhibitor, with IC₅₀ values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

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4

SNX-2112

4 Cited Publications

Cat. No.: HY-10214

CAS No.: 908112-43-6

Purity: 99.49%

Synonyms: PF-04928473

Target:

HSP Autophagy

Research Areas:

Cancer

SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a K_d of 16 nM for Hsp90 and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively . SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with K_ds of 4 nM, 6 nM and 484 nM, respectively .

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4

HM03

4 Cited Publications

Cat. No.: HY-125974

CAS No.: 500565-15-1

Purity: 99.34%

Target:

HSP

Research Areas:

Cancer

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

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3

PU-WS13

3 Cited Publications

Cat. No.: HY-18680

CAS No.: 1454619-14-7

Target:

HSP

Research Areas:

Cancer

PU-WS13 is a selective Grp94 inhibitor, with an EC₅₀ of 0.22 μM.

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3

Hexadecanoate-13C16 potassium

3 Cited Publications

Cat. No.: HY-W134007S1

CAS No.: 1458714-74-3

Hexadecanoate- ¹³C₁₆ (potassium) is the ¹³C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

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3

Palmitic acid-13C16 sodium

3 Cited Publications

Cat. No.: HY-N0830BS1

CAS No.: 2483736-17-8

Palmitic acid- ¹³C₁₆ sodium is the ¹³C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

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3

Palmitic acid-13C16

3 Cited Publications

Cat. No.: HY-N0830S6

CAS No.: 56599-85-0

Palmitic acid- ¹³C₁₆ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

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2

DGAT-1 inhibitor 2

2 Cited Publications

Cat. No.: HY-50670

CAS No.: 942999-61-3

Target:

Carnitine Palmitoyltransferase (CPT) Acyltransferase Reactive Oxygen Species (ROS) HSP PERK

Research Areas:

Metabolic Disease

DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC₅₀ values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity .

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