1 Result for "

GSK 137

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "GSK 137" in MCE Product Catalog:

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Cat. No.: HY-148631
CAS No.: 2728727-91-9
Target:  

BCL6

Research Areas:  

Inflammation/Immunology Cancer

GSK137 is an orally active BCL6 inhibitor. GSK137 competitively blocks the protein-protein interactions of BCL6 with the corepressors SMRT, NCOR1, and BCOR. GSK137 produces only weak cell cycle arrest in multiple BCL6-positive diffuse large B-cell lymphoma cell lines and has almost no effect on tumor cell viability. GSK137 inhibits the generation of mouse germinal center B cells and Tfh cells, and downregulates TNP-specific IgM and IgG antibody levels. GSK137 can be used for research related to diffuse large B-cell lymphoma .
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