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UDP-Galactose disodium

6 Cited Publications

Cat. No.: HY-114364

CAS No.: 137868-52-1

Purity: 99.42%

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite P2Y Receptor

UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

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1

1-Oleoyl-sn-glycero-3-phosphocholine

1 Cited Publications

Cat. No.: HY-W140439

CAS No.: 19420-56-5

Synonyms: 18:1 Lyso PC

Target:

Endogenous Metabolite

Research Areas:

Inflammation/Immunology

1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation .

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Pertussis Toxin

Cat. No.: HY-112779

CAS No.: 70323-44-3

Target:

Endogenous Metabolite

Research Areas:

Infection

Pertussis Toxin is a protein-based AB₅-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins .

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UDP-Galactose

Cat. No.: HY-150524

CAS No.: 2956-16-3

Category:

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite P2Y Receptor

UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose can be used to study cell signal transduction and substance metabolism .

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Osteogenic Growth Peptide (10-14)

Cat. No.: HY-107024

CAS No.: 105250-85-9

Purity: 99.77%

Synonyms: OGP(10-14); Historphin

Target:

Src

Research Areas:

Others

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor .

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HCAR2 agonist 1

Cat. No.: HY-156025

CAS No.: 1066676-21-8

Purity: 99.11%

Target:

Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:

Inflammation/Immunology

HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis .

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(-)-Isocorypalmine

Cat. No.: HY-N0927

CAS No.: 483-34-1

Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine

Category:

Alkaloids Monophenols Other Diseases Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:

Dopamine Receptor

(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .

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Mas7

Cat. No.: HY-P0258

CAS No.: 145854-59-7

Synonyms: Mastoparan 7

Target:

Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease

Mas7 (Mastoparan 7), a structural analogue of mastoparan, is an activator of heterotrimeric Gi proteins and its downstream effectors.

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MRS5698

Cat. No.: HY-110202

CAS No.: 1377273-00-1

Target:

Adenosine Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

MRS5698 is a selective G_i protein-coupled A₃ adenosine receptor (A₃AR) agonist, with K_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis .

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UDP-α-D-Galactose-13C disodium

Cat. No.: HY-114364S

Purity: ≥98.0%

UDP-α-D-Galactose- ¹³C disodium is the ¹³C labeled UDP-α-D-Galactose disodium. UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

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GPR81 agonist 2

Cat. No.: HY-148563

CAS No.: 1143024-28-5

Target:

Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:

Metabolic Disease

GPR81 agonist 2 is a GPR81 agonist with an EC₅₀ of 0.023 μM for the human receptor. GPR81 agonist 2 activates the lactate-sensing receptor GPR81, inhibits forskolin-stimulated cAMP production and GTP binding of G_i protein. GPR81 agonist 2 can be used for research on type 2 diabetes .

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