82

82 Publications Verification

Category:

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

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50

Urolithin A

50 Cited Publications

Cat. No.: HY-100599

CAS No.: 1143-70-0

Purity: 99.82%

Category:

Human Gut Microbiota Metabolites Microorganisms Monophenols Anti-aging Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer

Target:

Drug Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis Autophagy Apoptosis Endogenous Metabolite

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis .

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13

Trimethylamine N-oxide

13 Cited Publications

Cat. No.: HY-116084

CAS No.: 1184-78-7

Purity: ≥98.0%

Category:

Cardiovascular Disease Natural Products Microorganisms Other disease Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite

Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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13

Trimethylamine N-oxide dihydrate

13 Cited Publications

Cat. No.: HY-108915

CAS No.: 62637-93-8

Purity: ≥98.0%

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite

Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

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9

L-Lysine hydrochloride

9 Cited Publications

Cat. No.: HY-N0470

CAS No.: 657-27-2

Category:

Cardiovascular Disease Microorganisms Animals Amino acids Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Virus Protease Endogenous Metabolite

L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

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9

Gut restricted-7

9 Cited Publications

Cat. No.: HY-135747

CAS No.: 2553218-46-3

Purity: 98.23%

Synonyms: GR-7

Target:

Bacterial

Research Areas:

Infection

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .

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9

L-Lysine

9 Cited Publications

Cat. No.: HY-N0469

CAS No.: 56-87-1

Category:

Anti-aging Endocrine diseases Amino acids Endogenous metabolite Microorganisms Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer

Target:

Virus Protease Endogenous Metabolite HSV

L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation .

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7

Hyodeoxycholic acid

7 Cited Publications

Cat. No.: HY-N0169

CAS No.: 83-49-8

Synonyms: HDCA

Category:

Human Gut Microbiota Metabolites Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite

Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells.

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7

LP-533401

7 Cited Publications

Cat. No.: HY-15849

CAS No.: 945976-43-2

Purity: 98.02%

Target:

Tryptophan Hydroxylase

Research Areas:

Cardiovascular Disease Metabolic Disease

LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

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7

LP-533401 hydrochloride

7 Cited Publications

Cat. No.: HY-15849A

CAS No.: 1040526-12-2

Purity: 98.02%

Target:

Tryptophan Hydroxylase

Research Areas:

Cardiovascular Disease Metabolic Disease

LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.

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7

Hyodeoxycholic acid sodium

7 Cited Publications

Cat. No.: HY-N0169A

CAS No.: 10421-49-5

Synonyms: HDCA sodium

Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 µM in CHO cells .

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7

Geniposidic acid

7 Cited Publications

Cat. No.: HY-N0010

CAS No.: 27741-01-1

Category:

Iridoids Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer

Target:

FXR Sirtuin TNF Receptor Interleukin Related

Geniposidic acid is an orally active FXR modulator and SIRT6 activator. Geniposidic acid binds to the Ser332 and His447 sites on the FXR ligand-binding domain, thereby driving nuclear translocation, coactivator recruitment, and transcription of downstream bile acid and cholesterol metabolism-related genes. Geniposidic acid improves metabolic dysfunction-related fatty liver disease by activating the SIRT6 signaling pathway. Geniposidic acid inhibits inflammation and modulates gut microbiota to alleviate colitis. Geniposidic acid can be used in research on drug-induced liver injury, inflammatory bowel disease, metabolic dysfunction-related fatty liver disease, and metabolic dysfunction-related steatohepatitis .

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7

2-Ketoglutaric acid potassium

7 Cited Publications

Cat. No.: HY-W013636C

CAS No.: 997-43-3

Synonyms: Alpha-Ketoglutaric acid potassium

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

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5

Neurotensin

5 Cited Publications

Cat. No.: HY-P0234

CAS No.: 39379-15-2

Target:

Neurotensin Receptor

Research Areas:

Endocrinology Cancer

Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).

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5

Urolithin C

5 Cited Publications

Cat. No.: HY-135897

CAS No.: 165393-06-6

Purity: ≥98.0%

Category:

Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:

Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

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5

2'-Fucosyllactose

5 Cited Publications

Cat. No.: HY-N9965

CAS No.: 41263-94-9

Synonyms: 2'-FL

Category:

Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides

Target:

TNF Receptor Interleukin Related

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

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5

Baimaside

5 Cited Publications

Cat. No.: HY-N2183

CAS No.: 18609-17-1

Synonyms: Quercetin 3-O-sophoroside

Category:

Flavonols Flavonoids Other Diseases Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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