7 Results for "

H446 cells

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "H446 cells" in MCE Product Catalog:

Dicycloplatin
Dicycloplatin
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Cat. No.: HY-125010
CAS No.: 287402-09-9
Target:  

DNA/RNA Synthesis Apoptosis

Research Areas:  

Cancer

Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr .
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Topo I/II-IN-2
Topo I/II-IN-2
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Cat. No.: HY-170912
Target:  

Topoisomerase Apoptosis ROS Kinase Cytochrome P450 Caspase Bcl-2 Family PI3K Akt mTOR

Research Areas:  

Cancer

Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .
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2E-3-F16
2E-3-F16
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Cat. No.: HY-157292
CAS No.: 3002962-69-5
Target:  

Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cancer

2E-3-F16 is a anticancer agent. 2E-3-F16 exhibits tumor cell selectivity between NCI-H446 cancer cells and HBE cells. 2E-3-F16 enhances the sensitivity of A549 cells to Cisplatin (HY-17394) .
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WEE1-IN-11
WEE1-IN-11
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Cat. No.: HY-168180
CAS No.: 2975172-98-4
Target:  

Wee1

Research Areas:  

Cancer

WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC50 of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC50s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively .
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PI4KIII beta inhibitor 5
PI4KIII beta inhibitor 5
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Cat. No.: HY-172256
CAS No.: 3029506-23-5
Target:  

PI4K

Research Areas:  

Cancer

PI4KIII beta inhibitor 5 is a PI4KIIIβ inhibitor with an IC50 of 19 nM. PI4KIII beta inhibitor 5 can induce cancer cell apoptosis (Apoptosis), cell cycle arrest at the G2/M phase, and autophagy (Autophagy) by inhibiting the PI3K/AKT pathway. PI4KIII beta inhibitor 5 has also demonstrated significant antitumor activity in the H446 xenograft model of small cell lung cancer. PI4KIII beta inhibitor 5 can be used for research in the field of cancer therapy .
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(2S,3S)-Pterosin S 14-O-glucoside
(2S,3S)-Pterosin S 14-O-glucoside
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Cat. No.: HY-N16695
CAS No.: 62043-50-9
Category:  

Terpenoids Sesquiterpenes Pteridaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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