10

RG7834

10 Publications Verification

Cat. No.: HY-117650A

CAS No.: 2072057-17-9

Purity: 99.85%

Synonyms: RO 7020322; (S)-RO0321

Target:

HBV

Research Areas:

Infection

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC₅₀s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells .

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2

Adefovir dipivoxil

2 Cited Publications

Cat. No.: HY-B0255

CAS No.: 142340-99-6

Synonyms: GS 0840

Target:

HBV Orthopoxvirus HSV DNA/RNA Synthesis ATM/ATR CDK

Research Areas:

Infection Cancer

Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the KCTD12-CDK1 interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer .

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2

Adefovir

2 Cited Publications

Cat. No.: HY-B1826

CAS No.: 106941-25-7

Synonyms: GS-0393; PMEA

Target:

HBV Reverse Transcriptase

Research Areas:

Infection

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC₅₀ of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses .

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2

Vebicorvir

2 Cited Publications

Cat. No.: HY-109195

CAS No.: 2090064-66-5

Purity: 99.73%

Synonyms: ABI-H0731

Target:

HBV

Research Areas:

Infection Inflammation/Immunology

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC₅₀s from 1.84 μM to 7.3 μM .

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2

GLP-26

2 Cited Publications

Cat. No.: HY-124614

CAS No.: 2133017-36-2

Purity: 98.36%

Target:

HBV

Research Areas:

Infection

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC₅₀=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools . GLP-26 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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2

AT-130

2 Cited Publications

Cat. No.: HY-100028

CAS No.: 211364-06-6

Purity: 98.39%

Target:

HBV DNA/RNA Synthesis

Research Areas:

Infection Cancer

AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC₅₀ of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells .

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2

Matairesinol monoglucoside

2 Cited Publications

Cat. No.: HY-N8107

CAS No.: 34446-06-5

Category:

Monophenols Other Diseases Lignans Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields

Target:

STING IFNAR HBV

Matairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection .

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1

ALG-001075

1 Cited Publications

Cat. No.: HY-177022

CAS No.: 2495324-66-6

Target:

HBV

Research Areas:

Infection

ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB) .

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1

Clevudine

1 Cited Publications

Cat. No.: HY-13859

CAS No.: 163252-36-6

Purity: 99.93%

Synonyms: L-FMAU

Target:

HBV DNA/RNA Synthesis Orthopoxvirus

Research Areas:

Infection

Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice .

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1

HBV-IN-4

1 Cited Publications

Cat. No.: HY-131343

CAS No.: 2305897-84-9

Purity: 99.37%

Target:

HBV DNA/RNA Synthesis

Research Areas:

Infection

HBV-IN-4, a phthalazinone derivative, is a potent and orally active HBV DNA replication inhibitor with an IC₅₀ of 14 nM. HBV-IN-4 induces the formation of genome-free capsids and has potent anti-HBV potencies .

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Fialuridine

Cat. No.: HY-118122

CAS No.: 69123-98-4

Purity: 99.91%

Synonyms: FIAU; DRG-0098; NSC 678514

Target:

HSV HBV DNA/RNA Synthesis Orthopoxvirus Nucleoside Antimetabolite/Analog

Research Areas:

Infection

Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with K_is of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC₅₀ values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .

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Bepirovirsen

Cat. No.: HY-147217

CAS No.: 1403787-62-1

Purity: 97.10%

Synonyms: ISIS 505358

Target:

HBV

Research Areas:

Infection

Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen can be used for the research of chronic HBV infection. Bepirovirsen binding site sequence (GCACTTCGCTTCACCTCTGC) .

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Bepirovirsen sodium

Cat. No.: HY-147217A

CAS No.: 2563929-84-8

Purity: 98.44%

Synonyms: ISIS 505358 sodium

Target:

HBV

Research Areas:

Infection

Bepirovirsen (ISIS 505358) sodium is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen sodium leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen sodium can be used for the research of chronic HBV infection. Bepirovirsen sodium binding site sequence (GCACTTCGCTTCACCTCTGC) .

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Rubiadin

Cat. No.: HY-N0444

CAS No.: 117-02-2

Category:

Quinones Anthraquinones Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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