116

Plerixafor

116 Publications Verification

Cat. No.: HY-10046

CAS No.: 110078-46-1

Purity: 99.90%

Synonyms: AMD 3100; JM3100; SID791

Target:

CXCR HIV

Research Areas:

Infection Inflammation/Immunology Endocrinology Cancer

Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM ^[1] .

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90

Panobinostat

90 Cited Publications

Cat. No.: HY-10224

CAS No.: 404950-80-7

Purity: 99.37%

Synonyms: LBH589; NVP-LBH589; MTX 110

Target:

HDAC Autophagy HIV Apoptosis

Research Areas:

Cancer

Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities ^[1] . Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells . Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma .

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51

Ivermectin

51 Cited Publications

Cat. No.: HY-15310

CAS No.: 70288-86-7

Purity: 98.28%

Synonyms: MK-933; CD-5024; K-237

Category:

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import ^[1] . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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38

Dolutegravir

38 Cited Publications

Cat. No.: HY-13238

CAS No.: 1051375-16-6

Purity: 99.85%

Synonyms: S/GSK1349572

Target:

HIV Integrase HIV

Research Areas:

Infection

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) ^[1] .

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38

Dolutegravir sodium

38 Cited Publications

Cat. No.: HY-13238A

CAS No.: 1051375-19-9

Purity: 99.97%

Synonyms: S/GSK1349572 sodium

Target:

HIV Integrase HIV

Research Areas:

Infection

Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) ^[1] .

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31

Filgotinib

31 Cited Publications

Cat. No.: HY-18300

CAS No.: 1206161-97-8

Synonyms: GLPG0634

Target:

JAK HIV

Research Areas:

Cancer

Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC₅₀ values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease ^[1] .

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31

Filgotinib maleate

31 Cited Publications

Cat. No.: HY-18300A

CAS No.: 1802998-75-9

Synonyms: GLPG0634 maleate

Target:

JAK HIV

Research Areas:

Inflammation/Immunology

Filgotinib maleate (GLPG0634 maleate) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib maleate can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC₅₀ values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib maleate also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib maleate can be used in the study of rheumatoid arthritis and inflammatory bowel disease ^[1] .

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29

Ebselen

29 Cited Publications

Cat. No.: HY-13750

CAS No.: 60940-34-3

Purity: 99.58%

Synonyms: SPI-1005; PZ-51; CCG-39161

Target:

Calcium Channel Virus Protease HIV Phosphatase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker ^[1] . Ebselen potently inhibits M ^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .

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27

ONX-0914

27 Cited Publications

Cat. No.: HY-13207

CAS No.: 960374-59-8

Purity: 99.72%

Synonyms: PR-957

Target:

Proteasome Bacterial HIV

Research Areas:

Infection Inflammation/Immunology

ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 ^[1] .

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27

ONX-0914 TFA

27 Cited Publications

Cat. No.: HY-13207A

Purity: 98.01%

Synonyms: PR-957 TFA

Target:

Proteasome Bacterial HIV

Research Areas:

Infection Inflammation/Immunology

ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K_i=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 ^[1] .

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