6 Results for "

HMGCS2

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "HMGCS2" in MCE Product Catalog:

Cat. No.: HY-148334
CAS No.: 2855085-25-3
Purity:  99.95%
Research Areas:  

Cancer

MS8815 is a EZH2 PROTAC degrader, with a DC50 of 140 nM in MDA-MB-453 triple-negative breast cancer (TNBC) cells and an IC50 of 8.6 nM against human EZH2. MS8815 induces ubiquitin-proteasome system-mediated degradation of EZH2, reduces the levels of EED, SUZ12, FOXM1, H3K27me3 and global m6A, and increases the protein level of HMGCS2. MS8815 can be used in the research of breast cancer and prostate cancer [2] .
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Cat. No.: HY-RS06242
Research Areas:  

Others

HMGCS2 Human Pre-designed siRNA Set A contains three designed siRNAs for HMGCS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS18424
Research Areas:  

Others

Hmgcs2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hmgcs2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24905
Research Areas:  

Others

Hmgcs2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hmgcs2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-N2855
CAS No.: 19533-92-7
Synonyms: Aophitolic acid
Alphitolic acid (Aophitolic acid), an anti-inflammatory triterpenoid compound, is a selective HMGCS2 inhibitor (IC50 17.17 μM, Kd 5.6 μM). Alphitolic acid inhibits ORAI1/STIM1-mediated CRAC currents, store-operated calcium entry, the Akt-mTOR-NF-κB signaling pathway, p70S6K/S6/IκBα phosphorylation, NF-κB/Bcl-2 expression, and NO/TNF-α production, while upregulating p53 and downregulating MDM2. Alphitolic acid induces apoptosis (apoptosis) and autophagy (autophagy) through Beclin 1, Atg7, LC3B-II, and autophagosomes, inhibits oral squamous cell carcinoma proliferation/viability, and exhibits antibacterial/antimalarial/antioxidant activities. Alphitolic acid can be used in research on inflammatory diseases, allergic diseases, Tamoxifen (HY-13757A)-resistant breast cancer, oral squamous cell carcinoma, and inflammation [2] .
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Cat. No.: HY-P80968
Synonyms: HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS2

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse, Rat

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