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9 Results for "

HVA

" in MedChemExpress (MCE) Product Catalog:

Products (9)

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MRGPRX1 agonist 1

Cat. No.: HY-130118

CAS No.: 2377379-39-8

Purity: 99.95%

Target:

Research Areas:

Neurological Disease

MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC₅₀=50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca ²⁺ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain .

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Mofegiline hydrochloride

Cat. No.: HY-16677A

CAS No.: 120635-25-8

Synonyms: MDL72974A

Target:

Monoamine Oxidase VAP-1

Research Areas:

Neurological Disease

Mofegiline hydrochloride (MDL-72974A) is an orally active and blood-brain barrier-penetrant MAO-B/SSAO selective inhibitor, with an IC₅₀ of 3.6 nM for MAO-B and 10 nM for SSAO. Mofegiline hydrochloride is a cationic amphiphilic compound that can induce indirect sympathomimetic effects, lysosomal accumulation, hERG channel interactions, phospholipidosis, and cell death. Mofegiline hydrochloride protects mice from MPTP-induced depletion of striatal dopamine, DOPAC, and HVA. Mofegiline hydrochloride can be used in research related to Parkinson's disease .

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Ro 41-0960

Cat. No.: HY-125339

CAS No.: 125628-97-9

Purity: 98.0%

Target:

COMT Apoptosis

Research Areas:

Neurological Disease Cancer

Ro 41-0960 is a CNS-penetrant, orally active catechol-O-methyl transferase (COMT) inhibitor. Ro 41-0960 reduces dopamine catabolism, increases striatal dopamine and DOPAC levels, decreases striatal HVA levels, induces apoptosis, inhibits proliferation and extracellular matrix formation in uterine fibroid cells. Ro 41-0960 arrests or shrinks uterine fibroid lesions in rats. Ro 41-0960 can be used for the research of Parkinson’s disease, uterine leiomyomas, and breast cancer .

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Isohomovanillic acid

Cat. No.: HY-W002110

CAS No.: 1131-94-8

Synonyms: 3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid

Category:

Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Cancer

Target:

Drug Metabolite

Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease .

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