4

4 Cited Publications

Synonyms: NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; Hep-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

Host:

Rabbit

Application:

WB, IHC-P, IHC-F, ICC/IF

Reactivity:

Human, Mouse, Rat

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3

Anagliptin

3 Cited Publications

Cat. No.: HY-14877

CAS No.: 739366-20-2

Purity: 99.91%

Synonyms: SK-0403

Target:

Dipeptidyl Peptidase

Research Areas:

Cardiovascular Disease Metabolic Disease

Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

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3

S07-2010

3 Cited Publications

Cat. No.: HY-150644

CAS No.: 1223194-71-5

Purity: 99.79%

Research Areas:

Cancer

S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

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3

(Rac)-SHIN2

3 Cited Publications

Cat. No.: HY-134978

CAS No.: 2204289-53-0

Purity: 99.40%

Target:

SHMT Bacterial

Research Areas:

Others

(Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus .

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2

GLP-26

2 Cited Publications

Cat. No.: HY-124614

CAS No.: 2133017-36-2

Purity: 98.36%

Target:

HBV

Research Areas:

Infection

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC₅₀=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools . GLP-26 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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1

Lumiflavin

1 Cited Publications

Cat. No.: HY-121608

CAS No.: 1088-56-8

Purity: 99.79%

Synonyms: Lumiflavine

Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer .

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1

DDP-38003 dihydrochloride

1 Cited Publications

Cat. No.: HY-19612A

CAS No.: 1831167-98-6

Target:

Histone Demethylase

Research Areas:

Cancer

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM .

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1

Omidenepag

1 Cited Publications

Cat. No.: HY-17642

CAS No.: 1187451-41-7

Synonyms: UR-7276

Target:

Prostaglandin Receptor

Research Areas:

Endocrinology

Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC₅₀ of 1.1 nM. Omidenepag shows binding affinities (IC₅₀) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure .

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1

Leucomalachite green

1 Cited Publications

Cat. No.: HY-D0300

CAS No.: 129-73-7

Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant .

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1

Pumosetrag Hydrochloride

1 Cited Publications

Cat. No.: HY-19650

CAS No.: 194093-42-0

Synonyms: MKC-733; DDP-733

Target:

5-HT Receptor

Research Areas:

Metabolic Disease

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

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1

Heparanase/HPSE Protein, Human (CHO, His)

1 Cited Publications

Cat. No.: HY-P79276

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: HPSE; Endo-Glucoronidase; Heparanase; HPA1; HPSE1; HPR1; HSE1; Hpa1; HPA; Hep; Heparanase-1

Species:

Human

Source:

CHO

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1

Musk ketone

1 Cited Publications

Cat. No.: HY-N2045

CAS No.: 81-14-1

Target:

Environmental Pollutants Apoptosis Akt Cytochrome P450 PI3K

Research Areas:

Neurological Disease

Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis .

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1

RSV L-protein-IN-1

1 Cited Publications

Cat. No.: HY-115574

CAS No.: 851658-10-1

Purity: 98.09%

Target:

RSV

Research Areas:

Infection

RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC₅₀=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC₅₀=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection .

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Basic green 4

Cat. No.: HY-D0203

CAS No.: 569-64-2

Synonyms: Malachite green

Basic green 4 (Malachite green) is a cationic dye that is widely used as a bactericide in aquaculture and is also commonly used in laboratories for the determination of phosphates. Basic green 4 exhibits high cytotoxicity and carcinogenicity to mammalian cells, specifically shown by its IC₅₀ values of 2.03 µM for HEp-2 human laryngeal cells and 13.8 µM for Caco-2 human colorectal adenocarcinoma cells, and it can promote the development of liver tumors. The maximum absorbance wavelength is 621 nm .

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PROTAC PD-1/PD-L1 degrader-1

Cat. No.: HY-131183

CAS No.: 2447066-37-5

Purity: 99.52%

Target:

PROTACs PD-1/PD-L1

Research Areas:

Inflammation/Immunology

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC₅₀ of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner .

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HEP-1

Cat. No.: HY-P10056

CAS No.: 174641-44-2

Synonyms: Human ezrin peptide (324-337)

Target:

HIV HCV HPV Influenza Virus Interleukin Related

Research Areas:

Infection Inflammation/Immunology

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .

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EP2 receptor antagonist-3

Cat. No.: HY-176293

CAS No.: 1799626-16-6

Target:

Prostaglandin Receptor Amyloid-β

Research Areas:

Neurological Disease

EP2 receptor antagonist-3 is a selective EP2 receptor antagonist (IC₅₀: 8 nM in hEP2 SPA assay, 50 nM in hEP2 cAMP assay). EP2 receptor antagonist-3 increases the macrophage-mediated clearance of Amyloid-β plaques. EP2 receptor antagonist-3 can be used for the study of alzheimer’s diseases .

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PAT-505

Cat. No.: HY-107781

CAS No.: 1782070-22-7

Purity: 98.84%

Target:

Phosphodiesterase (PDE)

Research Areas:

Inflammation/Immunology

PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC₅₀ of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.

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Setipiprant

Cat. No.: HY-16635

CAS No.: 866460-33-5

Synonyms: ACT-129968; KYTH-105

Target:

Prostaglandin Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC₅₀ value of 6 nM. Setipiprant inhibits prostanoid receptors hDP₁ and hEP₂ with IC₅₀ values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis .

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