334 Results for "

Hsp90

" in MedChemExpress (MCE) Product Catalog:
Products (334)

334 Results for "Hsp90" in MCE Product Catalog:

282
Tamoxifen Citrate
Tamoxifen Citrate
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282 Publications Verification
Cat. No.: HY-13757
CAS No.: 54965-24-1
Purity:  99.93%
Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate
Target:  

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .
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282
Tamoxifen
Tamoxifen
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282 Publications Verification
Cat. No.: HY-13757A
CAS No.: 10540-29-1
Purity:  99.78%
Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Target:  

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:  

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) .
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74
Tanespimycin
Tanespimycin
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74 Cited Publications
Cat. No.: HY-10211
CAS No.: 75747-14-7
Purity:  99.01%
Synonyms: 17-AAG; NSC 330507; CP 127374
Target:  

HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic

Research Areas:  

Infection Cancer

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
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49
Ganetespib
Ganetespib
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49 Cited Publications
Cat. No.: HY-15205
CAS No.: 888216-25-9
Purity:  99.94%
Synonyms: STA-9090
Target:  

HSP Apoptosis

Research Areas:  

Cancer

Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3 .
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44
Geldanamycin
Geldanamycin
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44 Cited Publications
Cat. No.: HY-15230
CAS No.: 30562-34-6
Purity:  99.78%
Category:  

Infection Quinones Microorganisms Benzene Quinones Disease Research Fields Inflammation/Immunology

Target:  

HSP Bacterial Influenza Virus Antibiotic

Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
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27
Luminespib
Luminespib
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27 Cited Publications
Cat. No.: HY-10215
CAS No.: 747412-49-3
Purity:  99.74%
Synonyms: VER-52296; AUY922; NVP-AUY922
Target:  

HSP Autophagy Apoptosis

Research Areas:  

Cancer

Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively .
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17
Alvespimycin
Alvespimycin
0 Images
17 Cited Publications
Cat. No.: HY-10389
CAS No.: 467214-20-6
Purity:  99.59%
Synonyms: 17-DMAG; KOS-1022; NSC 707545
Target:  

HSP

Research Areas:  

Cancer

Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 nM.
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17
Alvespimycin hydrochloride
Alvespimycin hydrochloride
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17 Cited Publications
Cat. No.: HY-12024
CAS No.: 467214-21-7
Purity:  98.80%
Synonyms: 17-DMAG hydrochloride; KOS-1022 hydrochloride; BMS 826476
Target:  

HSP Apoptosis

Research Areas:  

Cancer

Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
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16
Gamitrinib TPP hexafluorophosphate
Gamitrinib TPP hexafluorophosphate
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16 Cited Publications
Cat. No.: HY-102007A
CAS No.: 1131626-47-5
Purity:  99.68%
Target:  

HSP

Research Areas:  

Cancer

Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
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15
Deguelin
Deguelin
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15 Cited Publications
Cat. No.: HY-13425
CAS No.: 522-17-8
Purity:  99.20%
Synonyms: (-)-Deguelin; (-)-cis-Deguelin
Category:  

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