38 Results for "

Human CRF

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "Human CRF" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P0086
CAS No.: 86784-80-7
Synonyms: Human CRF; Human corticotropin-releasing factor
Target:  

CRFR

Research Areas:  

Neurological Disease

Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
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1
1 Cited Publications
Cat. No.: HY-P1297
CAS No.: 120066-38-8
Target:  

CRFR

Research Areas:  

Neurological Disease

CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect .
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1
1 Cited Publications
Cat. No.: HY-P72599
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL10RB; CDW210B; Prev. D21S58; IL-10 Receptor Subunit Beta; Prev. D21S66; IL-10R Subunit Beta; Prev. CRFB4; IL-10R Subunit 2; IL-10R2; IL-10RB; CRF2-4; Cytokine Receptor Family II, Member 4; Interleukin-10 Receptor Subunit Beta; Cytokine Receptor Class-II
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P1752
CAS No.: 351999-18-3
Research Areas:  

Metabolic Disease

Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease .
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Cat. No.: HY-P1295
CAS No.: 176591-49-4
Synonyms: Urocortin (Human); Human urocortin; Human urocortin 1; Human urocortin I
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Urocortin, human, a 40-aa neuropeptide, acts as an agonist of endogenous CRF receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.
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Cat. No.: HY-12127
CAS No.: 459856-18-9
Purity:  99.97%
Synonyms: BMS-562086
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.
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Cat. No.: HY-P1296
CAS No.: 171543-83-2
Synonyms: Urocortin (Rattus norvegicus); Rat urocortin
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively .
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Cat. No.: HY-P1106A
Target:  

CFTR

Research Areas:  

Cardiovascular Disease

K41498 TFA is a highly selective CRF 2 receptor antagonist, with a Ki of 0.66 nM for human CRF2α receptor and a Ki of 0.62 nM for human CRF2β receptor. K41498 TFA inhibits cAMP accumulation in cells expressing CRF2. K41498 TFA antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 TFA undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues .
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Cat. No.: HY-P3019
CAS No.: 357952-09-1
Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion [1][2].
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Cat. No.: HY-P1752B
Research Areas:  

Metabolic Disease

Urocortin II, human acetate is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human acetate has an effect of promoting satiet and neuroprotective effect. Urocortin II, human acetate also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human acetate can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human acetate can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human acetate can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease .
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Cat. No.: HY-P1106
CAS No.: 434938-41-7
Target:  

CRFR

Research Areas:  

Cardiovascular Disease

K41498 is a highly selective CRF 2 receptor antagonist, with a Ki of 0.66 nM for human CRF2α receptor and a Ki of 0.62 nM for human CRF2β receptor. K41498 inhibits cAMP accumulation in cells expressing CRF2. K41498 antagonizes the hypotensive response induced by systemic administration of urocortin in conscious rats. K41498 undergoes radioiodination without loss of activity and serves for autoradiographic studies of native CRF2 receptors in rat brain and peripheral tissues .
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Cat. No.: HY-P3019A
Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion .
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Cat. No.: HY-P1542
CAS No.: 83930-33-0
Synonyms: Catostomus urotensin I
Target:  

CRFR

Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively .
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Cat. No.: HY-P1542B
Synonyms: Catostomus urotensin I TFA
Target:  

CRFR

Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively .
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Cat. No.: HY-14128
CAS No.: 268545-87-5
Synonyms: SB-723620
Target:  

CRFR

Research Areas:  

Neurological Disease

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.
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Cat. No.: HY-P1297A
Target:  

CRFR

Research Areas:  

Neurological Disease

CRF(6-33)(human) TFA is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) TFA competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) TFA has anti-obesity effect .
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Cat. No.: HY-P4542
CAS No.: 150646-45-0
Target:  

CRFR

Research Areas:  

Endocrinology

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition .
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Cat. No.: HY-P1296A
Synonyms: Urocortin (Rattus norvegicus) TFA; Rat urocortin TFA
Target:  

CRFR

Research Areas:  

Neurological Disease Endocrinology

Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively .
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Cat. No.: HY-12127R
CAS No.: 459856-18-9
Synonyms: BMS-562086 (Standard)
Pexacerfont (Standard) is the analytical standard of Pexacerfont. This product is intended for research and analytical applications. Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.
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Cat. No.: HY-14132
CAS No.: 1173435-64-7
Target:  

CRFR

Research Areas:  

Neurological Disease

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM) .
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