187

Belnacasan

187 Publications Verification

Cat. No.: HY-13205

CAS No.: 273404-37-8

Purity: 99.99%

Synonyms: VX-765

Target:

Caspase

Research Areas:

Inflammation/Immunology

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM .

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47

Apilimod

47 Cited Publications

Cat. No.: HY-14644

CAS No.: 541550-19-0

Purity: 99.80%

Synonyms: STA 5326; LAM-002A free base; AIT-101

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

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47

Apilimod mesylate

47 Cited Publications

Cat. No.: HY-14644A

CAS No.: 870087-36-8

Purity: 99.83%

Synonyms: STA 5326 mesylate; LAM-002A; AIT-101 mesylate

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

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7

JTE-607

7 Cited Publications

Cat. No.: HY-110133

CAS No.: 188791-09-5

Purity: 98.64%

Target:

Interleukin Related

Research Areas:

Inflammation/Immunology

JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

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2

Human CD8⁺ T Cells Negative Selection Kit

2 Cited Publications

Cat. No.: HY-K0351

MCE Human CD8⁺ T Cells Negative Selection Kit is designed to isolate CD8⁺ T cells from human peripheral blood mononuclear cells (PBMCs).

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1

RBN013209

1 Cited Publications

Cat. No.: HY-144987

CAS No.: 2597933-17-8

Purity: 98.84%

Target:

CD38 LAG-3 Tim3 PD-1/PD-L1

Research Areas:

Inflammation/Immunology Cancer

RBN013209 is an orally active small molecule inhibitor of CD38 with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD ⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .

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1

AZD2906

1 Cited Publications

Cat. No.: HY-113854

CAS No.: 1034148-15-6

Purity: 99.90%

Target:

Glucocorticoid Receptor

Research Areas:

Cardiovascular Disease Endocrinology

AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC₅₀s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively .

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1

Human CD3⁺ T Cells Negative Selection Kit

1 Cited Publications

Cat. No.: HY-K0304

MCE Human CD3⁺ T Cells Negative Selection Kit is designed for the isolation of CD3⁺ T cells from human peripheral blood mononuclear cells (PBMC).

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1

Human CD4⁺ T Cells Negative Selection Kit

1 Cited Publications

Cat. No.: HY-K0352

MCE Human CD4⁺ T Cells Negative Selection Kit is designed to isolate CD4⁺ T cells from human peripheral blood mononuclear cells (PBMCs).

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Ruvonoflast

Cat. No.: HY-156438

CAS No.: 2272917-13-0

Purity: 99.65%

Synonyms: NT-0796

Target:

NOD-like Receptor (NLR) Interleukin Related

Research Areas:

Neurological Disease

Ruvonoflast (NT-0796) is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. Ruvonoflast inhibits IL-1β release in human PBMC cells with an IC₅₀ value of 0.32 nM. Ruvonoflast is an isopropyl ester that undergoes intracellular conversion to Ruvonoflast, the carboxylic acid active species. Ruvonoflast reverses high fat diet-induced obesity, systemic inflammation and astrogliosis in the diet-induced obesity mouse model. Ruvonoflast is promising for research of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis .

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Pirmitegravir

Cat. No.: HY-130000

CAS No.: 2245231-10-9

Purity: 99.76%

Synonyms: STP0404

Target:

HIV Integrase HIV

Research Areas:

Infection

Pirmitegravir is a potent and first-in-class inhibitor of allosteric integrase (ALLINI) that targets LEDGF/p75 binding site. Pirmitegravir displays picomolar IC₅₀ in human PBMCs with a >24,000 therapeutic index against HIV-1. Pirmitegravir harbors outstanding anti-virus and safety properties .

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HPK1-IN-3

Cat. No.: HY-138568

CAS No.: 2739844-34-7

Purity: 98.61%

Target:

MAP4K

Research Areas:

Inflammation/Immunology

HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC₅₀ of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC₅₀ of 108 nM in human peripheral blood mononuclear cells (PBMCs) .

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STING agonist-45

Cat. No.: HY-177338

CAS No.: 2361424-97-5

Target:

STING Cyclic GMP-AMP Synthase IFNAR TNF Receptor Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

STING agonist-45 is a selective STING agonist (EC₅₀ = 0.28 μM). STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8 ⁺ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases .

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