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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
ICB-7
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "ICB-7" in MCE Product Catalog:
Cat. No.: HY-189933
CAS No.: 920836-30-2
Target:
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) SHP1 SHP2 STAT IFNAR Interleukin Related
Research Areas:
ICB-7 is an orally active ILT3/LILRB4 inhibitor with a Kd of 156 nM for hILT3 and a Kd of 262 nM for mouse ILT3. ICB-7 reduces SCG2-induced phosphorylation of SHP1, SHP2, and STAT3. In a co-culture model, ICB-7 restores IFN-γ and IL-2 secretion and decreases cell viability under SCG2 stimulation. In a syngeneic cancer model, ICB-7 inhibits tumor progression and reduces final tumor weight. ICB-7 can be used for research on colorectal cancer and acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
