91

IFN-gamma Protein, Human

91 Publications Verification

Cat. No.: HY-P7025

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNG; IMD69; Interferon gamma; IFG; IFN-gamma; IFI; Immune Interferon

Species:

Human

Source:

E. coli

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60

IFN-gamma Protein, Mouse

60 Cited Publications

Cat. No.: HY-P7071

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNG; IMD69; Interferon gamma; IFG; IFN-gamma; IFI; Immune Interferon

Species:

Mouse

Source:

E. coli

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47

Apilimod

47 Cited Publications

Cat. No.: HY-14644

CAS No.: 541550-19-0

Purity: 99.80%

Synonyms: STA 5326; LAM-002A free base; AIT-101

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

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47

Apilimod mesylate

47 Cited Publications

Cat. No.: HY-14644A

CAS No.: 870087-36-8

Purity: 99.83%

Synonyms: STA 5326 mesylate; LAM-002A; AIT-101 mesylate

Target:

Interleukin Related PIKfyve

Research Areas:

Inflammation/Immunology Cancer

Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

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29

Tirzepatide sodium

29 Cited Publications

Cat. No.: HY-P1731C

Synonyms: LY3298176 sodium

Target:

GLP Receptor Insulin Receptor Apoptosis mTOR

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .

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23

Itacitinib

23 Cited Publications

Cat. No.: HY-16997

CAS No.: 1334298-90-6

Synonyms: INCB039110

Target:

JAK STAT

Research Areas:

Inflammation/Immunology Cancer

Itacitinib (INCB039110) is an orally active selective inhibitor of JAK1 with an IC₅₀ value of 2 nM for human JAK1. Itacitinib inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .

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23

Itacitinib adipate

23 Cited Publications

Cat. No.: HY-16997A

CAS No.: 1334302-63-4

Synonyms: INCB039110 adipate

Target:

JAK STAT

Research Areas:

Inflammation/Immunology Cancer

Itacitinib adipate (INCB039110 adipate) is an orally active JAK1-selective inhibitor. Itacitinib adipate inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib adipate reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib adipate improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib adipate can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .

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16

T6167923

16 Cited Publications

Cat. No.: HY-19744

CAS No.: 2437475-16-4

Target:

MyD88

Research Areas:

Inflammation/Immunology

T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC₅₀s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .

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13

2-NP

13 Cited Publications

Cat. No.: HY-W013523

CAS No.: 65182-56-1

Target:

STAT JAK HSV

Research Areas:

Infection Cancer

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells .

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9

IFN-gamma Protein, Human (CHO)

9 Cited Publications

Cat. No.: HY-P7025A

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: IFNG; IMD69; Interferon gamma; IFG; IFN-gamma; IFI; Immune Interferon

Species:

Human

Source:

CHO

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8

Monalizumab

8 Cited Publications

Cat. No.: HY-P99032

CAS No.: 1228763-95-8

Synonyms: IPH2201

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .

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7

IFN-gamma Protein, Human (HEK293)

7 Cited Publications

Cat. No.: HY-P70610

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNG; IMD69; Interferon gamma; IFG; IFN-gamma; IFI; Immune Interferon

Species:

Human

Source:

HEK293

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7

Osunprotafib

7 Cited Publications

Cat. No.: HY-145923

CAS No.: 2489404-97-7

Purity: 99.38%

Synonyms: ABBV-CLS-484

Target:

Phosphatase STAT JAK

Research Areas:

Cancer

Osunprotafib (ABBV-CLS-484) is an orally active and selective active site PTPN1 (IC₅₀: 2.5 nM) and PTPN2(IC₅₀: 1.8 nM) inhibitor. Osunprotafib has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib increases the sensitivity of human cancer cell lines to IFNγ. Osunprotafib generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction .

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5

IL-18 Protein, Human

5 Cited Publications

Cat. No.: HY-P70591

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL18; Interleukin 18 (Interferon-gamma-Inducing Factor); Interleukin 18; IFN-gamma-Inducing Factor; IL-18; Interleukin-1 gamma; IL1F4; Iboctadekin; IGIF; IL-1 gamma; Interleukin-18; Interferon-gamma-Inducing Factor; IL-1g; Interferon gamma-Inducing Factor

Species:

Human

Source:

E. coli

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5

IL-18 Protein, Mouse (solution)

5 Cited Publications

Cat. No.: HY-P73181

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: IL18; Interleukin 18 (Interferon-gamma-Inducing Factor); Interleukin 18; IFN-gamma-Inducing Factor; IL-18; Interleukin-1 gamma; IL1F4; Iboctadekin; IGIF; IL-1 gamma; Interleukin-18; Interferon-gamma-Inducing Factor; IL-1g; Interferon gamma-Inducing Factor

Species:

Mouse

Source:

E. coli

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5

2'-Fucosyllactose

5 Cited Publications

Cat. No.: HY-N9965

CAS No.: 41263-94-9

Synonyms: 2'-FL

Category:

Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides

Target:

TNF Receptor Interleukin Related

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

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