1371

3-Methyladenine

1371 Publications Verification

Cat. No.: HY-19312

CAS No.: 5142-23-4

Synonyms: 3-MA

Category:

Natural Products Microorganisms Endogenous metabolite Disease Research Fields Cancer

Target:

PI3K Autophagy Mitophagy Endogenous Metabolite

3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K .

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466

Deferoxamine mesylate

466 Cited Publications

Cat. No.: HY-B0988

CAS No.: 138-14-7

Synonyms: Desferrioxamine B mesylate; DFOM

Target:

Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

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466

Deferoxamine

466 Cited Publications

Cat. No.: HY-B1625

CAS No.: 70-51-9

Synonyms: Deferoxamine B; Deferriferrioxamine B; Deferrioxamine

Target:

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt Autophagy

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

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266

Angiotensin II human

266 Cited Publications

Cat. No.: HY-13948

CAS No.: 4474-91-3

Purity: 99.98%

Synonyms: Angiotensin II; Ang II; DRVYIHPF

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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266

Angiotensin II human acetate

266 Cited Publications

Cat. No.: HY-13948A

CAS No.: 68521-88-0

Purity: 99.62%

Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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266

Angiotensin II human TFA

266 Cited Publications

Cat. No.: HY-13948B

CAS No.: 2761969-44-0

Purity: 98.84%

Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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204

Trichostatin A

204 Cited Publications

Cat. No.: HY-15144

CAS No.: 58880-19-6

Purity: 99.53%

Synonyms: TSA

Category:

Anti-aging Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:

Organoid HDAC

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC₅₀ value of 1.8 nM for HDAC .

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82

4μ8C

82 Cited Publications

Cat. No.: HY-19707

CAS No.: 14003-96-4

Synonyms: IRE1 Inhibitor III

Target:

IRE1

Research Areas:

Metabolic Disease

4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.

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76

LY2109761

76 Cited Publications

Cat. No.: HY-12075

CAS No.: 700874-71-1

Purity: 99.72%

Target:

TGF-β Receptor Autophagy

Research Areas:

Cancer

LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with K_is of 38 nM and 300 nM, respectively.

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64

Heparin sodium salt

64 Cited Publications

Cat. No.: HY-17567A

CAS No.: 9041-08-1

Synonyms: Sodium heparin; Sodium heparinate

Target:

Exosomes Thrombin Factor Xa Autophagy

Research Areas:

Cardiovascular Disease Cancer

Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.

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59

Filipin complex

59 Cited Publications

Cat. No.: HY-N6716

CAS No.: 11078-21-0

Category:

Microorganisms Antifungal Antibiotics Other Diseases Antiviral Disease Research Disease Research Fields Other Antibiotics

Target:

Fungal Antibiotic

Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) .

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