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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
IL-1 converting enzyme
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "IL-1 converting enzyme" in MCE Product Catalog:
187
187 Publications Verification
Synonyms: VX-765
Target:
Research Areas:
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
39
Target:
Research Areas:
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
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7
Category:
Quinones Plant Anthraquinones Rumex crispus Linn. Extract Disease Research Fields Inflammation/Immunology Polygonaceae Extract
Target:
5
2
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .
2
2 Cited Publications
Cat. No.: HY-P72117
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CASP1; Caspase 1, Apoptosis-Related Cysteine Peptidase (Interleukin 1, Beta, Convertase); Prev. IL1BC; CDNA FLJ59442, Highly SimILar To Caspase-1; Caspase-1; CDNA FLJ58540, Highly SimILar To Caspase-1; ICE; Interleukin 1-B converting enzyme; P45; CASP1 Ni
Species:
Human
Source:
E. coli
1
Target:
Research Areas:
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment .
Cat. No.: HY-N4090
CAS No.: 59914-91-9
Cat. No.: HY-13205R
CAS No.: 273404-37-8
Synonyms: VX-765 (Standard)
Target:
Research Areas:
Belnacasan (Standard) is the analytical standard of Belnacasan. This product is intended for research and analytical applications. Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
Target:
Research Areas:
SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting M pro (IC50 of 30 nM) .
Cat. No.: HY-P5890
CAS No.: 153604-27-4
Target:
Research Areas:
Cat. No.: HY-P5890A
Target:
Research Areas:
Cat. No.: HY-N4090R
CAS No.: 59914-91-9
Cat. No.: HY-W650842
CAS No.: 172702-58-8
Cat. No.: HY-P2630
CAS No.: 208264-84-0
Target:
Research Areas:
Cat. No.: HY-P87052
Synonyms: CARDIAK; RICK; RIP2; UNQ277/PRO314/PRO34092; RIPK2; Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; Tyrosine-protein kinase RIPK2; CARD-containing IL-1 beta ICE-kinase; RIP-2
Cat. No.: HY-16990R
CAS No.: 178603-78-6
Synonyms: Caspase-1 Inhibitor II (Standard)
Target:
Research Areas:
Ac-YVAD-cmk (Standard) is the analytical standard of Ac-YVAD-cmk (HY-16990). This product is intended for research and analytical applications. Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
