35

SR-717

35 Publications Verification

Cat. No.: HY-131454

CAS No.: 2375421-09-1

Purity: 99.89%

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

SR-717 is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

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35

SR-717 free acid

35 Publications Verification

Cat. No.: HY-131454A

CAS No.: 2375420-34-9

Purity: 98.05%

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

SR-717 free acid is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

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29

RO8191

29 Cited Publications

Cat. No.: HY-W063968

CAS No.: 691868-88-9

Synonyms: CDM-3008; RO4948191

Target:

IFNAR JAK STAT HCV HBV

Research Areas:

Infection

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC₅₀ of 200 nM for HCV replicon . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity .

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7

RIG012

7 Cited Publications

Cat. No.: HY-147124

CAS No.: 2642218-43-5

Purity: 98.21%

Target:

IFNAR

Research Areas:

Infection Cancer

RIG012 is a potent RIG-I inhibitor with an IC₅₀ of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression .

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4

ChX710

4 Cited Publications

Cat. No.: HY-112951

CAS No.: 2438721-44-7

Purity: 99.91%

Target:

STING

Research Areas:

Cancer

ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.

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2

dBRD9

2 Cited Publications

Cat. No.: HY-117690

CAS No.: 2170679-45-3

Purity: 99.75%

Target:

PROTACs Epigenetic Reader Domain IFNAR

Research Areas:

Cancer

dBRD9 is a BRD9 PROTAC degrader. dBRD9 reduces the binding of the ISGF3 complex to ISG promoters, decreases the level of ISG induction downstream of IFNAR signaling, and reduces the chromatin binding of BRD4 at BRD9 co-binding sites. dBRD9 can be used in research related to acute myeloid leukemia .

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2

dBRD9 dihydrochloride

2 Cited Publications

Cat. No.: HY-117690A

CAS No.: 2341840-98-8

Target:

PROTACs Epigenetic Reader Domain IFNAR

Research Areas:

Cancer

dBRD9 dihydrochloride is a BRD9 PROTAC degrader. dBRD9 dihydrochloride reduces the binding of the ISGF3 complex to ISG promoters, decreases the level of ISG induction downstream of IFNAR signaling, and reduces the chromatin binding of BRD4 at BRD9 co-binding sites. dBRD9 dihydrochloride can be used in research related to acute myeloid leukemia .

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1

STING-IN-15

1 Cited Publications

Cat. No.: HY-173425

CAS No.: 2912492-05-6

Target:

STING IFNAR TNF Receptor Interleukin Related

Research Areas:

Inflammation/Immunology

STING-IN-15 is an orally active STING inhibitor, with an IC₅₀ of 116 nM against h-STING and an IC₅₀ of 96.3 nM against m-STING. STING-IN-15 inhibits the STING signaling pathway in cells, reduces the secretion of IFN-β and IP-10, downregulates the expression of ISG15, ISG56 and TNF-α, and suppresses the phosphorylation of TBK1/IRF3. STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases .

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1

Dimethyl biphenyl-4,4'-dicarboxylate

1 Cited Publications

Cat. No.: HY-128854

CAS No.: 792-74-5

Purity: ≥98.0%

Target:

Biochemical Assay Reagents JAK STAT IFNAR DNA/RNA Synthesis HBV

Research Areas:

Infection Metabolic Disease

Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B .

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1

JAK-IN-23

1 Cited Publications

Cat. No.: HY-151262

CAS No.: 3031837-35-8

Purity: 98.90%

Target:

JAK STING NF-κB STAT

Research Areas:

Inflammation/Immunology

JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC₅₀ values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC₅₀ values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD) .

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