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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
270 Results for "
IgG Fc
" in MedChemExpress (MCE) Product Catalog:
Products (270)
270 Results for "IgG Fc" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-P99340
CAS No.: 2423014-07-5
Synonyms: VIR-7831 (WT IgG1); GSK-4182136 (WT IgG1)
Sotrovimab (VIR-7831) (WT IgG1) is a human IgG1κ monoclonal antibody targeting the Sarbecovirus subgenus; it is capable of neutralizing SARS-CoV-2, SARS-CoV-1, and various other coronaviruses. Sotrovimab (WT IgG1) is a monoclonal antibody that retains the native, wild-type IgG1 Fc structure without any engineered modifications; unlike Sotrovimab (HY-P99340A), it does not contain the M428L or N434S mutations. Sotrovimab (WT IgG1) can be used for research on COVID-19 .
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4 Cited Publications
Synonyms: CTLA4lg; BMS-188667
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4 Cited Publications
Synonyms: CTLA4lg (powder); BMS-188667 (powder); Orencia
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3 Cited Publications
Cat. No.: HY-P99355
CAS No.: 1356922-05-8
Synonyms: Anti-ACVR2B Reference Antibody (WT IgG1); BYM338 (WT IgG1)
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Bimagrumab (Anti-ACVR2B Reference Antibody) (WT IgG1) is a human monoclonal antibody that retains a native wild-type Fc region and is capable of blocking the activin type II receptor (ActRII). Bimagrumab (WT IgG1) can be used in research concerning pathological muscle loss and weakness. .
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Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .
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2 Cited Publications
Cat. No.: HY-108801
CAS No.: 862111-32-8
Synonyms: VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1
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2 Cited Publications
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1 Cited Publications
Cat. No.: HY-P990876
CAS No.: 2911580-96-4
Synonyms: PF-06480605 (WT IgG1); RVT-3101 (WT IgG1)
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Afimkibart (PF-06480605) (WT IgG1) is a fully human monoclonal antibody that selectively inhibits trimeric tumor necrosis factor-like ligand 1A (TL1A). Afimkibart (WT IgG1) is a monoclonal antibody that retains the native, wild-type IgG1 Fc structure without any engineered modifications; unlike Afimkibart (HY-P990876A), it does not contain the L234A, L235A, or G237A mutations. Afimkibart (WT IgG1) can be used for the research of inflammatory bowel disease .
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1 Cited Publications
Cat. No.: HY-E70365A
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IdeS (Immobilized, Microspin) is a resin that covalently couples IdeS protease to agarose beads and cleaves IgG at specific sites to generate F(ab')2 and Fc fragments. After IdeS (Immobilized, Microspin) digestion, F(ab')2 and Fc fragments are obtained in the solution without IdeS enzyme.
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1 Cited Publications
Cat. No.: HY-P70705
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FcGR3A; CD16; Prev. FcGR3; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Prev. FcG3; Fc Of IgG Low Affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low Affinity IIIa Receptor Isoform 1; FcGRIIIA; Immunoglobulin G Fc Receptor III; CD16a; Neutrophil-Specific Antigen NA; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; Fc-Gamma Receptor IIIb (CD16); Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Gamma Receptor III-A; Fc Fragment Of IgG Receptor IIIa; Fc-Gamma RIIIa; IgG Fc Receptor III-A; Fc-Gamma RIII; IgG Fc Receptor III-2; FcgammaRIIIA; Fc-Gamma RIII-Alpha; FcRIIIA; CD16a Antigen; FcRIIIa; CD16-II; FcR-10; IGFR3; FcRIII; CD16A; IMD20; Fc Gamma Receptor IIIa; Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment
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Human
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HEK293
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Cat. No.: HY-P99033
CAS No.: 1905409-39-3
Synonyms: BTCT-4465A; RG-7828; RO7030816
Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). The Fc region of Mosunetuzumab incorporates a "knob-into-hole" structural modification and an N297G point mutation to achieve heterodimerization and eliminate Fc glycosylation, thereby effectively silencing antibody effector functions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
