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8 Results for "

Induction assay

" in MedChemExpress (MCE) Product Catalog:

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Xevinapant hydrochloride

13 Cited Publications

Cat. No.: HY-13208

CAS No.: 1071992-57-8

Purity: 98.01%

Synonyms: AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride

Target:

IAP Apoptosis

Research Areas:

Cancer

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors .

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Filastatin

Cat. No.: HY-124701

CAS No.: 431996-53-1

Purity: 99.27%

Target:

Fungal

Research Areas:

Infection

Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC₅₀ of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .

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5-Hydroxytryptamine creatinine sulfate monohydrate

Cat. No.: HY-W010973

CAS No.: 61-47-2

Category:

Natural Products Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite 5-HT Receptor

5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock .

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STING modulator-3

Cat. No.: HY-148606

CAS No.: 2839639-94-8

Target:

STING

Research Areas:

Cancer

STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an K_i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .

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Gp(2′-5′)Ap sodium

Cat. No.: HY-159857

Synonyms: Gp(2′-5′)Ap(3′) sodium; 2'5'-GpAp sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium

Target:

Nucleoside Antimetabolite/Analog

Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

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